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<p>The current study reports antibacterial and antidiarrheal activity of aqueous extract of <i>Prosopis cineraria</i> bark (PCAqE) against <i>Enterobacter cloacae</i> isolated from drinking water. In antidiarrheal assays, PCAqE (400&#xa0;mg/kg) reduced defecation frequency by 57.29% and fecal weight to 1.053 ± 0.128&#xa0;g compared to 2.26 ± 0.25&#xa0;g in controls. It also inhibited 89.11% of charcoal meal transit in gastrointestinal motility tests, outperforming the standard drug loperamide (47.87% inhibition). Histopathological evaluation showed PCAqE preserved intestinal mucosal integrity, preventing tissue damage. The LC–MS/MS analysis of PCAqE revealed 19 different active chemical constituents, mainly flavonoids, flavone, and glycosyloxyflavone families that could be linked to observed antibacterial, antioxidant, and anti-inflammatory properties in PCAqE. Overall, the findings support the use of PCAqE as a promising natural remedy for managing bacterial infections and diarrheal diseases, especially those related to waterborne pathogens.</p>

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Evaluation of antibacterial and antidiarrheal properties of Prosopis cineraria in Albino rats

  • 期刊论文

  • 发表日期：

    2025年7月25日

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  • Divya Sharma,
  • Annu Bhardwaj,
  • Siddhi Gaur,
  • Saraswati Patel,
  • Smita Jain,
  • Kanika Verma,
  • Shiva Gudlawar,
  • Sarvesh Paliwal,
  • Jaya Dwivedi,
  • Swapnil Sharma

摘要

The current study reports antibacterial and antidiarrheal activity of aqueous extract of Prosopis cineraria bark (PCAqE) against Enterobacter cloacae isolated from drinking water. In antidiarrheal assays, PCAqE (400 mg/kg) reduced defecation frequency by 57.29% and fecal weight to 1.053 ± 0.128 g compared to 2.26 ± 0.25 g in controls. It also inhibited 89.11% of charcoal meal transit in gastrointestinal motility tests, outperforming the standard drug loperamide (47.87% inhibition). Histopathological evaluation showed PCAqE preserved intestinal mucosal integrity, preventing tissue damage. The LC–MS/MS analysis of PCAqE revealed 19 different active chemical constituents, mainly flavonoids, flavone, and glycosyloxyflavone families that could be linked to observed antibacterial, antioxidant, and anti-inflammatory properties in PCAqE. Overall, the findings support the use of PCAqE as a promising natural remedy for managing bacterial infections and diarrheal diseases, especially those related to waterborne pathogens.