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<p>Keratinase is a proteolytic enzyme specialized in the degradation of keratin-rich materials and has garnered significant attention for its potential in various biotechnological applications. This review provides an overview of keratinase, focusing on its structure, classification, function, biochemical properties, mechanisms of action and diverse applications. Keratinase plays an important role in bioremediation and stands out prominently, as it facilitates the eco-friendly degradation of keratinaceous waste materials addressing environmental concerns by reducing pollution and waste accumulation. Moreover, in the textile industry, keratinase plays a pivotal role in bio-pretreatment processes, enhancing the dyeing and finishing properties of animal fibers such as wool and silk. Beyond textiles, this enzyme contributes significantly to animal feed production by hydrolyzing keratin-rich byproducts into digestible components, thereby fostering the creation of high-protein feeds. Its impact extends to the cosmetic and pharmaceutical realms, where keratinase finds use in skincare formulations and in treating certain dermatological conditions owing to its ability to modify and break down keratin structures. By&#xa0;assisting in the removal of dead tissue, it demonstrates potential in biological applications for wound healing. Additionally, the challenges and future perspectives on the commercial scalability of keratinase production and its integration into various sectors are discussed.</p>

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Keratinase and its diverse applications

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Varsha Thadiyan,
  • Vibhuti Sharma,
  • Reena Gupta

摘要

Keratinase is a proteolytic enzyme specialized in the degradation of keratin-rich materials and has garnered significant attention for its potential in various biotechnological applications. This review provides an overview of keratinase, focusing on its structure, classification, function, biochemical properties, mechanisms of action and diverse applications. Keratinase plays an important role in bioremediation and stands out prominently, as it facilitates the eco-friendly degradation of keratinaceous waste materials addressing environmental concerns by reducing pollution and waste accumulation. Moreover, in the textile industry, keratinase plays a pivotal role in bio-pretreatment processes, enhancing the dyeing and finishing properties of animal fibers such as wool and silk. Beyond textiles, this enzyme contributes significantly to animal feed production by hydrolyzing keratin-rich byproducts into digestible components, thereby fostering the creation of high-protein feeds. Its impact extends to the cosmetic and pharmaceutical realms, where keratinase finds use in skincare formulations and in treating certain dermatological conditions owing to its ability to modify and break down keratin structures. By assisting in the removal of dead tissue, it demonstrates potential in biological applications for wound healing. Additionally, the challenges and future perspectives on the commercial scalability of keratinase production and its integration into various sectors are discussed.