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<p>Superparamagnetic iron oxide nanoparticles (SPIONs) have gained attention as a very promising theragnostic nano-drug delivery systems having inherent antimicrobial potential. Loading pharmacological agents such as curcumin onto these nanocarriers offers a novel strategy to address multidrug-resistant (MDR) bacterial infections. In this study, a multifunctional nanoplatform was developed by engineering curcumin-loaded mesoporous silica-coated SPIONs (CUR-mSiO₂-SPIONs) for combating MDR pathogens and their biofilms. The nanoparticles were systematically characterized for their structural, optical, magnetic, and colloidal properties, confirming successful synthesis and functionalization. The nanocarriers exhibited pH-responsive curcumin release (pH 5.5 and 7.4), favoring the acidic microenvironment to combat against bacterial infections. CUR-mSiO<sub>2</sub>-SPIONs shows synergistic enhancement of curcumin’s activity when it is delivered leading to effective growth inhibition and strong biofilm suppression of the MDR pathogens. Mechanistic investigations further indicated that the nanoparticles promoted excessive reactive oxygen species generation and cell wall membrane disruption, ultimately leading to cell death, contributing to their potent antibacterial action. Overall, these findings provide clear evidence of the potential of CUR-mSiO₂-SPIONs as an efficient nanotherapeutic approach for the treatment of biofilm-associated MDR infections.</p>

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Targeted disruption of Biofilm-Associated MDR pathogens using Curcumin-Loaded mesoporous spions

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • Annesha Roy,
  • Deepak Khatak,
  • Amiya Kumar Patel,
  • Kajal Kumari,
  • Ramovatar Meena

摘要

Superparamagnetic iron oxide nanoparticles (SPIONs) have gained attention as a very promising theragnostic nano-drug delivery systems having inherent antimicrobial potential. Loading pharmacological agents such as curcumin onto these nanocarriers offers a novel strategy to address multidrug-resistant (MDR) bacterial infections. In this study, a multifunctional nanoplatform was developed by engineering curcumin-loaded mesoporous silica-coated SPIONs (CUR-mSiO₂-SPIONs) for combating MDR pathogens and their biofilms. The nanoparticles were systematically characterized for their structural, optical, magnetic, and colloidal properties, confirming successful synthesis and functionalization. The nanocarriers exhibited pH-responsive curcumin release (pH 5.5 and 7.4), favoring the acidic microenvironment to combat against bacterial infections. CUR-mSiO2-SPIONs shows synergistic enhancement of curcumin’s activity when it is delivered leading to effective growth inhibition and strong biofilm suppression of the MDR pathogens. Mechanistic investigations further indicated that the nanoparticles promoted excessive reactive oxygen species generation and cell wall membrane disruption, ultimately leading to cell death, contributing to their potent antibacterial action. Overall, these findings provide clear evidence of the potential of CUR-mSiO₂-SPIONs as an efficient nanotherapeutic approach for the treatment of biofilm-associated MDR infections.