<p>This research delves into obstructions to accepting Industry 5.0 principles within last-mile delivery (LMD) networks. The research establishes a methodical framework for the sustainable vision and the real-world difficulties of LMD. Relevant stakeholders identified 15 impediments and assessed them using a thorough examination. According to the study’s findings, the main obstacles include organizational resistance to change, worker skill gaps, the difficulty of technological integration, and the immaturity of important technologies. Market volatility and data privacy issues were found to have less impact on this system. The main obstacles to implementing Industry 5.0 in last-mile delivery are data security, ineffective human–robot collaboration, and technology interoperability. These interrelated issues are the focus of logistics firms’ development of workable execution plans. Logistics companies target these interconnected challenges to formulate viable implementation strategies. In addition to improving delivery performance, removing these obstacles can promote environmental sustainability. Companies must use collaborative robots, adopt sustainable operations, establish strong data governance, and manage expenses in order to achieve this. These actions can promote green logistics, boost stakeholder trust, and improve operational efficiency. In order to develop more robust, human-centered, and sustainable last-mile delivery systems, this study analyzes these implementation hurdles and lays the groundwork for future research and practical solutions.</p>