<p>There are some issues in the teaching of software quality assurance and testing courses in universities. For example, students’ learning enthusiasm is not high, and teaching effectiveness is not as expected. To solve these problems, in this study, a new mode of inquiry-based flipped classroom teaching is constructed to effectively address the issue of outdated teaching methods. The method of “knowledge transfer” is innovated to realize digital teaching, ubiquitous learning, and mobile learning to enhance the degree of “knowledge internalization” and ultimately to realize the “solidification of knowledge.” By actively exploring innovative learning modes, students’ ability to engage in “independent inquiry” is cultivated, thereby realizing the “spirit of innovation”. By utilizing front-loaded case studies, the inquiry-oriented course model was proactively carried out. Online platforms are utilized to assign prerequisites, and success stories are presented to students to build a visual impression of the Software Quality Assurance and Testing course. Practice has shown that this teaching model can strengthen student learning outcomes and achieve better teaching results and applied in similar courses.</p>