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<p>Epilepsy is a chronic neurological disorder characterized by recurrent seizures caused by abnormal neuronal excitability. As many patients remain resistant to antiepileptic drugs, alternative therapies such as the ketogenic diet (KD) have gained attention. This study evaluated the effects of KD on <i>Drosophila melanogaster</i> para^bss^ mutants, an established epilepsy model. Flies were fed wheat cream agar supplemented with KD at 25, 50, and 75&#xa0;mg/mL. KD significantly improved fecundity and fertility, with the greatest effect observed at 75&#xa0;mg/mL. Protein content increased in a dose-dependent manner, while carbohydrate levels were elevated in both sexes, indicating metabolic adaptation. Catalase activity increased in males and females, whereas superoxide dismutase activity increased in males but slightly decreased in females, suggesting sex-specific antioxidant responses. These findings demonstrate that KD modulates reproductive performance, metabolism, and oxidative stress responses, contributing to improved physiological homeostasis and supporting its potential therapeutic role in epilepsy.</p> Graphical abstract

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Pre- and post-adult effects of ketogenic diet on reproduction, metabolism, and oxidative stress in Drosophila para bang senseless mutants

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Megha B. Abbigeri,
  • Bothe Thokchom,
  • Sapam Riches Singh,
  • Santoshkumar Gataraddi,
  • Ramesh Babu Yarajarla

摘要

Epilepsy is a chronic neurological disorder characterized by recurrent seizures caused by abnormal neuronal excitability. As many patients remain resistant to antiepileptic drugs, alternative therapies such as the ketogenic diet (KD) have gained attention. This study evaluated the effects of KD on Drosophila melanogaster para^bss^ mutants, an established epilepsy model. Flies were fed wheat cream agar supplemented with KD at 25, 50, and 75 mg/mL. KD significantly improved fecundity and fertility, with the greatest effect observed at 75 mg/mL. Protein content increased in a dose-dependent manner, while carbohydrate levels were elevated in both sexes, indicating metabolic adaptation. Catalase activity increased in males and females, whereas superoxide dismutase activity increased in males but slightly decreased in females, suggesting sex-specific antioxidant responses. These findings demonstrate that KD modulates reproductive performance, metabolism, and oxidative stress responses, contributing to improved physiological homeostasis and supporting its potential therapeutic role in epilepsy.

Graphical abstract