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<p>Fruits are important sources of bioactive compounds with recognized antioxidant and hypoglycemic potential. This study evaluated the phenolic composition and in vitro antioxidant, anti-acetylcholinesterase (AChE), and hypoglycemic activities of ethanolic extracts from widely consumed fruits. Total phenolics and flavonoids were quantified by Folin–Ciocalteu and AlCl₃ methods, respectively. Antioxidant activity was assessed by DPPH, ABTS, and β-carotene assays, while hypoglycemic potential was evaluated via inhibition of α-amylase, α-glucosidase, and lipase. Açaí showed the highest phenolic (156.87 ± 0.52&#xa0;mg GAE/g) and flavonoid contents (115.78 ± 0.91&#xa0;mg QE/g), as well as the strongest antioxidant activity (IC<sub>50</sub>: 9.75 ± 0.43&#xa0;µg/mL for DPPH). Red grape also exhibited high phenolic content (130.10 ± 0.33&#xa0;mg GAE/g) and the most potent hypoglycemic activity, with superior inhibition of α-amylase (IC<sub>50</sub> 6.32 ± 0.94&#xa0;µg/mL) and α-glucosidase (IC<sub>50</sub> = 5.91 ± 0.62&#xa0;µg/mL). Blueberry and strawberry showed the highest AChE inhibition (IC<sub>50</sub>≈ 10.4–10.5&#xa0;µg/mL). Additionally, açaí and guava demonstrated lipase inhibition comparable to orlistat (IC<sub>50</sub> ≈ 6.97&#xa0;µg/mL). These results highlight açaí and red grape as promising sources of multifunctional bioactive compounds for nutraceutical applications targeting metabolic disorders.</p>

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Multifunctional in vitro bioactivity of commonly consumed fruits: Inhibition of free radicals and hypoglycemic enzymes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月30日

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  • Sara Ingrid Caetano Gomes Barbosa,
  • Lucas Soares Frota,
  • Daniela Ribeiro Alves,
  • Wildson Max Barbosa da Silva,
  • Maria Rayane Correia de Oliveira,
  • Ronaldo Teixeira de Meneses,
  • Selene Maia de Morais

摘要

Fruits are important sources of bioactive compounds with recognized antioxidant and hypoglycemic potential. This study evaluated the phenolic composition and in vitro antioxidant, anti-acetylcholinesterase (AChE), and hypoglycemic activities of ethanolic extracts from widely consumed fruits. Total phenolics and flavonoids were quantified by Folin–Ciocalteu and AlCl₃ methods, respectively. Antioxidant activity was assessed by DPPH, ABTS, and β-carotene assays, while hypoglycemic potential was evaluated via inhibition of α-amylase, α-glucosidase, and lipase. Açaí showed the highest phenolic (156.87 ± 0.52 mg GAE/g) and flavonoid contents (115.78 ± 0.91 mg QE/g), as well as the strongest antioxidant activity (IC50: 9.75 ± 0.43 µg/mL for DPPH). Red grape also exhibited high phenolic content (130.10 ± 0.33 mg GAE/g) and the most potent hypoglycemic activity, with superior inhibition of α-amylase (IC50 6.32 ± 0.94 µg/mL) and α-glucosidase (IC50 = 5.91 ± 0.62 µg/mL). Blueberry and strawberry showed the highest AChE inhibition (IC50≈ 10.4–10.5 µg/mL). Additionally, açaí and guava demonstrated lipase inhibition comparable to orlistat (IC50 ≈ 6.97 µg/mL). These results highlight açaí and red grape as promising sources of multifunctional bioactive compounds for nutraceutical applications targeting metabolic disorders.