Scholarlink

<p>In this work, we comprehensively evaluated the composition of gut microbiota from phylum to species level after goat milk intake and analyzed their functional characterization. Male mice were used, 12 for each of the two groups: a control group that received sterile distilled water and a treated group that received goat milk, and the compositional and functional features of intestinal microbiota were compared between two groups by metagenomic analysis. The result revealed that at the species level, goat milk could increase the relative abundance of <i>Bacteroides uniformis</i> and <i>Lactobacillus murinus</i>, and reduce the relative abundance of several pathogenic bacteria, such as <i>Helicobacter cinaedi</i>,<i> Bacteroides fragilis</i>,<i> Clostridium difficile</i>,<i> Clostridium clostridioforme</i> and <i>Clostridium symbiosum</i>, representing that goat milk intake had a beneficial effect on gut microbiota by promoting the proliferation of certain beneficial bacteria and/or inhibiting the growth of specific harmful bacteria in the gut of mice. The KEGG functional analysis showed that PTEN, SIRT1 and dicer associated genes in the pathway of microRNA in cancer were upregulated significantly after goat milk intake, implying its potential impact on the disease control and prevention.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Goat milk affects the compositional and functional features of gut microbiota revealed by metagenomic analysis

  • 期刊论文

  • 发表日期：

    2026年3月16日

查看全文
  • Yufang Liu,
  • Yaling Yang,
  • Fuxin Zhang

摘要

In this work, we comprehensively evaluated the composition of gut microbiota from phylum to species level after goat milk intake and analyzed their functional characterization. Male mice were used, 12 for each of the two groups: a control group that received sterile distilled water and a treated group that received goat milk, and the compositional and functional features of intestinal microbiota were compared between two groups by metagenomic analysis. The result revealed that at the species level, goat milk could increase the relative abundance of Bacteroides uniformis and Lactobacillus murinus, and reduce the relative abundance of several pathogenic bacteria, such as Helicobacter cinaedi, Bacteroides fragilis, Clostridium difficile, Clostridium clostridioforme and Clostridium symbiosum, representing that goat milk intake had a beneficial effect on gut microbiota by promoting the proliferation of certain beneficial bacteria and/or inhibiting the growth of specific harmful bacteria in the gut of mice. The KEGG functional analysis showed that PTEN, SIRT1 and dicer associated genes in the pathway of microRNA in cancer were upregulated significantly after goat milk intake, implying its potential impact on the disease control and prevention.

Graphical abstract