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<p>Lingonberry (<i>Vaccinium vitis-idaea</i> L.) is a dominant hypoarctic species that grows throughout the Kola Arctic. The leaves of the plant have significant pharmaceutical properties due to their high content of bioactive components. Complete extraction of phenolic compounds and obtaining an extract with high antioxidant activity require the development of extraction conditions. Optimization of conditions for ultrasound-assisted extraction using a water–ethanol mixture with single-factorial and Box-Behnken designs of experiments was carried out for the first time in this study. The kinetics of extraction of polyphenolic compounds have been approximated using a second-order reaction equation, with the calculation of rate constants and equilibrium yields of the target group of substances. Optimal extraction conditions have been established: the process duration is 30&#xa0;min, the solvent concentration is 50 vol.% ethanol, ultrasonic power is 90 W, particle size of ground plant material is 1 micron, volume-to-mass ratio is 50:1, and temperature is 57&#xa0;°C. The HPLC method determined the presence of myricetin, quercetin, arbutin, and chlorogenic acid. The results obtained will help to develop technologies for the production of herbal medicines from leaves of <i>V. vitis-idaea</i> for the pharmaceutical industry and cosmetology.</p>

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Optimization of ultrasonic extraction of biologically active substances from leaves of Vaccinium vitis-idaea L. using water–ethanol mixtures

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Lidiya Sereda,
  • Oleg Matusevich,
  • Natalia Artemkina,
  • Nikita Tsvetov

摘要

Lingonberry (Vaccinium vitis-idaea L.) is a dominant hypoarctic species that grows throughout the Kola Arctic. The leaves of the plant have significant pharmaceutical properties due to their high content of bioactive components. Complete extraction of phenolic compounds and obtaining an extract with high antioxidant activity require the development of extraction conditions. Optimization of conditions for ultrasound-assisted extraction using a water–ethanol mixture with single-factorial and Box-Behnken designs of experiments was carried out for the first time in this study. The kinetics of extraction of polyphenolic compounds have been approximated using a second-order reaction equation, with the calculation of rate constants and equilibrium yields of the target group of substances. Optimal extraction conditions have been established: the process duration is 30 min, the solvent concentration is 50 vol.% ethanol, ultrasonic power is 90 W, particle size of ground plant material is 1 micron, volume-to-mass ratio is 50:1, and temperature is 57 °C. The HPLC method determined the presence of myricetin, quercetin, arbutin, and chlorogenic acid. The results obtained will help to develop technologies for the production of herbal medicines from leaves of V. vitis-idaea for the pharmaceutical industry and cosmetology.