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<p>Arabinoxylan, the preeminent constituent of hemicellulose B present in cereal bran, is widely recognized for its myriad physiological benefits, encompassing antioxidant, anticarcinogenic, immunomodulatory, intestinal protective, and prebiotic activities, thereby underscoring its significance in promoting health and wellness. Recent research extracted arabinoxylan (AX) from corn bran and fractionated it into AX-1–1, AX-2–1, and AX-3–1, which were purified and structurally analyzed. These fractions had average molecular weights of 287, 305, and 280&#xa0;kDa, respectively, and consisted mainly of arabinose and xylose, along with other saccharides, with A/X ratios of 0.78, 1.02, and 0.92. Their anti-inflammatory effects were tested on RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). AX-3–1 showed the strongest activity by downregulating the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and suppressing the NF-κB pathway, reducing inflammatory cytokine secretion. These results highlight the potential of corn by-products in new applications and suggest AX as a food supplement for anti-inflammatory purposes.</p> Graphical abstract <p>Extraction, characterization, and anti-inflammatory activity evaluation of arabinoxylan.</p>

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Arabinoxylan derived from corn bran by-product: structural characterization and anti-inflammatory activity

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Boyu Xiong,
  • Yuying Jiang,
  • Ziying Zhan,
  • Li Tao,
  • Lei Yu,
  • Lihua Lian

摘要

Arabinoxylan, the preeminent constituent of hemicellulose B present in cereal bran, is widely recognized for its myriad physiological benefits, encompassing antioxidant, anticarcinogenic, immunomodulatory, intestinal protective, and prebiotic activities, thereby underscoring its significance in promoting health and wellness. Recent research extracted arabinoxylan (AX) from corn bran and fractionated it into AX-1–1, AX-2–1, and AX-3–1, which were purified and structurally analyzed. These fractions had average molecular weights of 287, 305, and 280 kDa, respectively, and consisted mainly of arabinose and xylose, along with other saccharides, with A/X ratios of 0.78, 1.02, and 0.92. Their anti-inflammatory effects were tested on RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS). AX-3–1 showed the strongest activity by downregulating the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and suppressing the NF-κB pathway, reducing inflammatory cytokine secretion. These results highlight the potential of corn by-products in new applications and suggest AX as a food supplement for anti-inflammatory purposes.

Graphical abstract

Extraction, characterization, and anti-inflammatory activity evaluation of arabinoxylan.