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<p>The antithrombotic effect of <i>Clerodendranthus spicatus</i> (Thunb.) C.Y.Wu phenolic acid compounds (cat whisker grass phenolic acid compounds, CWGPACs) was verified in vivo. Experimental results showed that CWGPACs could effectively reduce the degree of black tail in thrombotic mice. CWGPACs could also reduce the levels of MDA in serum of mice with thrombosis and increase the levels of T-SOD, and CAT. CWGPACs down-regulated NF-κB p65, ICAM-1, VCAM-1, and selectin E mRNA expression in the tail vein vascular tissue of thrombotic mice and up-regulated Cu/Zn-SOD, Mn-SOD, CAT, and GSH-Px expression in liver and kidney tissues of thrombotic mice. CWGPACs up-regulated the expression of <i>Bacteroidetes</i>, <i>Lactobacillus</i>, and <i>Bifidobacterium</i> and down-regulated the expression of <i>Firmicutes</i>. CWGPACs contained caffeic acid, isoquercetin, rosmarinic acid, baicalin, and baicalein. These results showed that CWGPACs could reduce inflammation and inhibit thrombosis in thrombotic mice and that the effect of CWGPACs improved at high concentrations.</p>

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Clerodendranthus spicatus (Thunb.) C.Y.Wu phenolic acid compounds reduce carrageenan-induced thrombosis by enhancing the antioxidant capacity of mice

  • 期刊论文

  • 发表日期：

    2025年11月28日

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  • Xueyan Liao,
  • Xuhua Heng,
  • Mengwei Wang,
  • Jing Song,
  • Kechun Wang

摘要

The antithrombotic effect of Clerodendranthus spicatus (Thunb.) C.Y.Wu phenolic acid compounds (cat whisker grass phenolic acid compounds, CWGPACs) was verified in vivo. Experimental results showed that CWGPACs could effectively reduce the degree of black tail in thrombotic mice. CWGPACs could also reduce the levels of MDA in serum of mice with thrombosis and increase the levels of T-SOD, and CAT. CWGPACs down-regulated NF-κB p65, ICAM-1, VCAM-1, and selectin E mRNA expression in the tail vein vascular tissue of thrombotic mice and up-regulated Cu/Zn-SOD, Mn-SOD, CAT, and GSH-Px expression in liver and kidney tissues of thrombotic mice. CWGPACs up-regulated the expression of Bacteroidetes, Lactobacillus, and Bifidobacterium and down-regulated the expression of Firmicutes. CWGPACs contained caffeic acid, isoquercetin, rosmarinic acid, baicalin, and baicalein. These results showed that CWGPACs could reduce inflammation and inhibit thrombosis in thrombotic mice and that the effect of CWGPACs improved at high concentrations.