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<p>The use of self-nanoemulsifying drug delivery systems (SNEDDSs) offers significant benefits for the administration of lipophilic drugs. Therefore, the current research focuses on developing and evaluating SNEDDSs of DHA-rich microalgae oil fortified with oil-soluble vitamins for better palatability, strength, dispersibility, stability, and bioavailability. A simple stirring method was used to develop the SNEDDS formulations, which were optimized based on in-vitro characterization. The optimized formulation (FSN-5) displayed a nano globule size (67.4 ± 11.3&#xa0;nm), PDI (0.280 ± 0.03), and zeta potential (-17.9 ± 5.9 mV). Additionally, it demonstrated a cloud point of 96 ± 2℃, rapid self-emulsification rate (48 ± 6&#xa0;s), and pH (7.16 ± 0.2), which are essential criteria for the development of elegant and stable SNEDDSs. Subsequent stability assessments also confirmed the increased physical and oxidative stability of the developed SNEDDS formulation. Also, compared to the pure DHA-rich microalgae oil, DHA absorption from the optimized SNEDDS formulation was higher, according to ex-vivo and in-vivo absorption studies. Thus, the findings underscore the importance of a fortified oral palatable SNEDDS formulation featuring a higher DHA strength of 140&#xa0;mg/ml and vitamins (A, D, and E). Thus, it can be used as a supplement in gestation period to both mother and foetus.</p>

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Fortified self-nanoemulsifying drug delivery system (SNEDDS) of docosahexaenoic acid as a novel food: an in-vitro and in-vivo assessment

  • 期刊论文

  • 发表日期：

    2025年8月12日

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  • Shubham Thakur,
  • Aashveen Chhina,
  • Riya Shivgotra,
  • Subheet Kumar Jain

摘要

The use of self-nanoemulsifying drug delivery systems (SNEDDSs) offers significant benefits for the administration of lipophilic drugs. Therefore, the current research focuses on developing and evaluating SNEDDSs of DHA-rich microalgae oil fortified with oil-soluble vitamins for better palatability, strength, dispersibility, stability, and bioavailability. A simple stirring method was used to develop the SNEDDS formulations, which were optimized based on in-vitro characterization. The optimized formulation (FSN-5) displayed a nano globule size (67.4 ± 11.3 nm), PDI (0.280 ± 0.03), and zeta potential (-17.9 ± 5.9 mV). Additionally, it demonstrated a cloud point of 96 ± 2℃, rapid self-emulsification rate (48 ± 6 s), and pH (7.16 ± 0.2), which are essential criteria for the development of elegant and stable SNEDDSs. Subsequent stability assessments also confirmed the increased physical and oxidative stability of the developed SNEDDS formulation. Also, compared to the pure DHA-rich microalgae oil, DHA absorption from the optimized SNEDDS formulation was higher, according to ex-vivo and in-vivo absorption studies. Thus, the findings underscore the importance of a fortified oral palatable SNEDDS formulation featuring a higher DHA strength of 140 mg/ml and vitamins (A, D, and E). Thus, it can be used as a supplement in gestation period to both mother and foetus.