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<p>Punicic acid has been shown to exhibit anti-cardiovascular, anti-osteoporosis, antidiabetic, anti-inflammatory, and anticancer activities in both in vitro and in vivo studies. In this study, the inclusion complex of fatty acids (FA) from pomegranate seed oil, containing more than 70% punicic acid, with β-cyclodextrin (bCD) was comprehensively investigated. The inclusion complex (FA_bCD) was prepared by the co-precipitation method under optimal conditions: a bCD concentration of 10&#xa0;mM and a molar ratio of bCD to FA of 2:1. The characteristics of the complex were studied using IR, XRD, TGA, SEM, and <sup>1</sup>H NMR spectrometry. The geometries of the inclusion complex of punicic acid with bCD (Pu_bCD) were explored using DFT calculations (B3LYP/6-31G) with semi-empirical dispersion correction. The FA_bCD complex was formed in a 1:1 stoichiometry, and a stability constant of 1365&#xa0;M<sup>−1</sup> at 40&#xa0;°C was determined. The antioxidant activity and ability to inhibit MCF-7 cell growth of the inclusion complex and fatty acid were compared, providing a theoretical basis for the further development and utilization of FA_bCD complexes.</p> Graphical abstract <p></p>

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Inclusion complex of fatty acids of pomegranate seed oil with betacyclodextrin: preparation, characterization and bioactivity

  • 期刊论文

  • 发表日期：

    2025年3月12日

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  • Van Anh Nguyen,
  • Anh Thi Ngoc Vu,
  • Hai Thi Huynh,
  • Van Tung Nguyen,
  • Gia Man Phung,
  • Ngoc Thuy Nguyen,
  • Victor Ivanovic Deineka,
  • Olga Kovalchukova

摘要

Punicic acid has been shown to exhibit anti-cardiovascular, anti-osteoporosis, antidiabetic, anti-inflammatory, and anticancer activities in both in vitro and in vivo studies. In this study, the inclusion complex of fatty acids (FA) from pomegranate seed oil, containing more than 70% punicic acid, with β-cyclodextrin (bCD) was comprehensively investigated. The inclusion complex (FA_bCD) was prepared by the co-precipitation method under optimal conditions: a bCD concentration of 10 mM and a molar ratio of bCD to FA of 2:1. The characteristics of the complex were studied using IR, XRD, TGA, SEM, and 1H NMR spectrometry. The geometries of the inclusion complex of punicic acid with bCD (Pu_bCD) were explored using DFT calculations (B3LYP/6-31G) with semi-empirical dispersion correction. The FA_bCD complex was formed in a 1:1 stoichiometry, and a stability constant of 1365 M−1 at 40 °C was determined. The antioxidant activity and ability to inhibit MCF-7 cell growth of the inclusion complex and fatty acid were compared, providing a theoretical basis for the further development and utilization of FA_bCD complexes.

Graphical abstract