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Purpose <p>Intracholecystic papillary neoplasm [ICPN] is a rare entity comprising of 0.4% of all cholecystectomies. The WHO 5th edition consider this gallbladder neoplasm as a separate novel entity characterized as a grossly visible, mass-forming, noninvasive epithelial neoplasm. Overlapping clinical and radiological features make ICPN a great mimicker of malignancy. We conducted this study to determine the clinicopathological spectrum and invasive potential of ICPN.</p> Methods <p>We did a retrospective analysis over last 3 years and studied their clinicopathological features and follow up data. A total 210 cholecystectomy specimens were received from the department of surgical oncology among which 19 cases were excluded in view of preoperative neoadjuvant chemotherapy. The remaining cases were retrospectively reviewed after retrieval of clinical information from the electronic medical records. Both gross and histopathological parameters were assessed by two trained oncopathologists.</p> Results <p>In a review of 191upfront cholecystectomy specimens, ICPN was identified in 15 cases [7.85%]. Among these, 11 cases [73.3%] exhibited invasive component. Female preponderance was noted and mean age of presentation was 58.4 ± 6.89 years. Abdominal pain was the presenting symptoms with mean duration of 2.58 months. The body and fundus were the most common location. Intestinal differentiation [6 cases; 40%] was the commonest mono-typical cell morphology. All the cases of invasive ICPN were staged according to the level of invasion.</p> Conclusion <p>Body and fundus was the most common location. ICPN with friable excrescence, intestinal differentiation and high grade dysplasia were associated with adenocarcinoma of gall bladder. Significant association with an invasive malignancy may be attributed by selection bias.</p>

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Intracholecystic Papillary Neoplasm of The Gall Bladder: Clinicopathological Spectrum and Invasive Potential

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • Anupam Sarma,
  • Moumita Sengupta,
  • Gaurav Das,
  • Shiraj Ahmed,
  • Lopamudra Kakoti,
  • Rukmini Bezbaruah,
  • Shivaji Sharma

摘要

Purpose

Intracholecystic papillary neoplasm [ICPN] is a rare entity comprising of 0.4% of all cholecystectomies. The WHO 5th edition consider this gallbladder neoplasm as a separate novel entity characterized as a grossly visible, mass-forming, noninvasive epithelial neoplasm. Overlapping clinical and radiological features make ICPN a great mimicker of malignancy. We conducted this study to determine the clinicopathological spectrum and invasive potential of ICPN.

Methods

We did a retrospective analysis over last 3 years and studied their clinicopathological features and follow up data. A total 210 cholecystectomy specimens were received from the department of surgical oncology among which 19 cases were excluded in view of preoperative neoadjuvant chemotherapy. The remaining cases were retrospectively reviewed after retrieval of clinical information from the electronic medical records. Both gross and histopathological parameters were assessed by two trained oncopathologists.

Results

In a review of 191upfront cholecystectomy specimens, ICPN was identified in 15 cases [7.85%]. Among these, 11 cases [73.3%] exhibited invasive component. Female preponderance was noted and mean age of presentation was 58.4 ± 6.89 years. Abdominal pain was the presenting symptoms with mean duration of 2.58 months. The body and fundus were the most common location. Intestinal differentiation [6 cases; 40%] was the commonest mono-typical cell morphology. All the cases of invasive ICPN were staged according to the level of invasion.

Conclusion

Body and fundus was the most common location. ICPN with friable excrescence, intestinal differentiation and high grade dysplasia were associated with adenocarcinoma of gall bladder. Significant association with an invasive malignancy may be attributed by selection bias.