Objective <p>To evaluate the safety and efficacy of endoscopic large-diameter balloon dilation in patients with benign esophagogastric anastomotic strictures following esophagectomy for cancer.</p> Methods <p>A retrospective descriptive study was conducted on 20 patients with esophagogastric anastomotic strictures after esophagectomy for cancer, treated with balloon dilation from January 2021 to June 2023 at the Department of Gastrointestinal Surgery, Viet Duc University Hospital.</p> Results <p>Among 167 patients who underwent esophagectomy, 20 patients (12%) developed anastomotic strictures. All were male, with a mean age of 55.1 ± 5.8 years, and 100% presented with varying degrees of dysphagia. The average time to the onset of stricture symptoms was 2.75 ± 2.1 months, with 50% having a history of prior anastomotic leakage. No complications were observed in this small cohort during the dilation procedures. The mean number of dilation sessions was 3.75 ± 1.6. The success rate was 90%, and the rate of early restenosis at the 3-month follow-up was 27.8%; no additional late recurrences were observed during follow-up.</p> Conclusion <p>Endoscopic large-diameter balloon dilation for esophagogastric anastomotic strictures following esophagectomy for cancer appears to be a safe and effective minimally invasive treatment that improves symptoms and may enhance patients’ quality of life.</p>