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Purpose <p>This study aimed to estimate the responsiveness and minimal clinically important difference (MCID) of the 6-minute walk distance (6MWD) and isometric knee extension force (IKEF) from within 1 week before to 1 week after radical surgery in patients with gastric cancer (GC). </p> Methods <p>Patients with GC (<i>n</i> = 29) scheduled for radical surgery were enrolled. To estimate the MCID of the 6MWD and IKEF, an anchor-based approach was applied using the EuroQol 5-Dimension 5-Level questionnaire as anchors. The effect size (ES) and standardized response mean (SRM) of the 6MWD and IKEF were calculated to evaluate responsiveness, and the receiver operating characteristic (ROC) curve was used to estimate the MCID of the 6MWD and IKEF. </p> Results <p>Of the 29 patients, 22 were included in the analysis. The absolute value of ES and SRM values for the 6MWD were 0.83 and 1.35, and for the IKEF, 0.27 and 0.71, respectively. The ROC curve indicated that the optimal cut-off value for estimating the MCID of the 6MWD was -170 m (area under the curve [AUC] = 0.938 [95% confidence interval {CI}: 0.837−1.000]), and for estimating the IKEF, -6.7 kgf (AUC = 0.812 [95% CI: 0.592−1.000]).</p> Conclusion <p>During the perioperative period from within 1 week before to 1 week after surgery, the responsiveness of the 6MWD was favorable, but that of the IKEF was comparatively weaker. The estimated MCIDs were -170 m for the 6MWD and -6.7 kgf for the IKEF in patients with GC.</p>

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Responsiveness and Minimal Clinically Important Difference of Physical Function During Perioperative Period in Patients with Gastric Cancer

  • 期刊论文

  • 发表日期：

    2026年2月25日

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  • Takuya Yanagisawa,
  • Noriatsu Tatematsu,
  • Mioko Horiuchi,
  • Saki Migitaka,
  • Shotaro Yasuda,
  • Keita Itatsu,
  • Tomoyuki Kubota,
  • Hideshi Sugiura

摘要

Purpose

This study aimed to estimate the responsiveness and minimal clinically important difference (MCID) of the 6-minute walk distance (6MWD) and isometric knee extension force (IKEF) from within 1 week before to 1 week after radical surgery in patients with gastric cancer (GC).

Methods

Patients with GC (n = 29) scheduled for radical surgery were enrolled. To estimate the MCID of the 6MWD and IKEF, an anchor-based approach was applied using the EuroQol 5-Dimension 5-Level questionnaire as anchors. The effect size (ES) and standardized response mean (SRM) of the 6MWD and IKEF were calculated to evaluate responsiveness, and the receiver operating characteristic (ROC) curve was used to estimate the MCID of the 6MWD and IKEF.

Results

Of the 29 patients, 22 were included in the analysis. The absolute value of ES and SRM values for the 6MWD were 0.83 and 1.35, and for the IKEF, 0.27 and 0.71, respectively. The ROC curve indicated that the optimal cut-off value for estimating the MCID of the 6MWD was -170 m (area under the curve [AUC] = 0.938 [95% confidence interval {CI}: 0.837−1.000]), and for estimating the IKEF, -6.7 kgf (AUC = 0.812 [95% CI: 0.592−1.000]).

Conclusion

During the perioperative period from within 1 week before to 1 week after surgery, the responsiveness of the 6MWD was favorable, but that of the IKEF was comparatively weaker. The estimated MCIDs were -170 m for the 6MWD and -6.7 kgf for the IKEF in patients with GC.