Scholarlink

<p>Achieving clear surgical margins in oral cancer surgery is crucial for reducing recurrence rate and improving patient survival. However, intraoperative margin assessment remains challenging due to limitations in visual and tactile evaluation. Indocyanine green (ICG) fluorescence imaging has emerged as a potential adjunct for real-time surgical guidance, though its intraoperative utility in oral cancer is not yet fully established.&#xa0;This prospective, non-randomized feasibility study included 75 patients undergoing surgery for oral cancer. Untagged ICG was administered prior to anesthesia induction. Intraoperative near-infrared imaging was used to delineate tumor margins, which were compared with gross clinical assessment and histopathologic evaluation. The need for intraoperative margin revision, final margin status, and the predictive performance of ICG-derived margins were analyzed.&#xa0;Margin revision was performed in 28% of cases. Final histopathology revealed clear margins in 57.3%, close margins in 30.7%, and involved margins in 12% of patients. ICG-delineated margins differed significantly from both gross and histologic margins (<i>p</i> &lt; 0.01). A deep ICG margin &gt; 4.5&#xa0;mm predicted the absence of revision with 98.1% sensitivity and 75.5% overall accuracy.&#xa0;ICG fluorescence imaging is not recommended as a standalone modality for intraoperative margin assessment in oral cancer surgery but may be a valuable adjunct to conventional evaluation methods. Standardized protocols and larger validation studies are warranted to confirm its role in surgical oncology practice.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Indocyanine Green Fluorescence-Guided Surgery for Margin Assessment in Oral Cancer : A Feasibility Study

  • 期刊论文

  • 发表日期：

    2025年12月23日

查看全文
  • Sreeram MP.,
  • Karthik N Rao,
  • Radhika Kapahtia,
  • Teertha Sadhashiv Shetty,
  • Hari PS,
  • BS Srinath,
  • Narayana Subramaniam

摘要

Achieving clear surgical margins in oral cancer surgery is crucial for reducing recurrence rate and improving patient survival. However, intraoperative margin assessment remains challenging due to limitations in visual and tactile evaluation. Indocyanine green (ICG) fluorescence imaging has emerged as a potential adjunct for real-time surgical guidance, though its intraoperative utility in oral cancer is not yet fully established. This prospective, non-randomized feasibility study included 75 patients undergoing surgery for oral cancer. Untagged ICG was administered prior to anesthesia induction. Intraoperative near-infrared imaging was used to delineate tumor margins, which were compared with gross clinical assessment and histopathologic evaluation. The need for intraoperative margin revision, final margin status, and the predictive performance of ICG-derived margins were analyzed. Margin revision was performed in 28% of cases. Final histopathology revealed clear margins in 57.3%, close margins in 30.7%, and involved margins in 12% of patients. ICG-delineated margins differed significantly from both gross and histologic margins (p < 0.01). A deep ICG margin > 4.5 mm predicted the absence of revision with 98.1% sensitivity and 75.5% overall accuracy. ICG fluorescence imaging is not recommended as a standalone modality for intraoperative margin assessment in oral cancer surgery but may be a valuable adjunct to conventional evaluation methods. Standardized protocols and larger validation studies are warranted to confirm its role in surgical oncology practice.