<p>To estimate the prevalence of Stauffer syndrome in clear cell type renal cell carcinoma, describe the clinical characteristics and mortality of patients with Stauffer syndrome, and determine predictors of mortality in these patients. A retrospective cohort study was conducted at a tertiary care hospital in India, using data from January 2001 to March 2015 with 193 patients with clear cell variant of RCC. Data were collected from hospital records. Kaplan–Meier survival curves, and Cox proportional hazard models were used for analysis. Out of 193 patients with RCC, 32 (16.6%; 95% CI: 11.2 to 22.0%) were diagnosed with Stauffer syndrome. The mean age was 53.9&#xa0;years (SD 11&#xa0;years), with 83.9% (<i>n</i> = 162) being male. Haematuria (<i>n</i> = 11, 34.4%) and abdominal pain (<i>n</i> = 7, 21.9%) were the commonest symptoms. Among liver function tests, the most frequently elevated enzyme was alkaline phosphatase (<i>n</i> = 9, 28.1%), followed by total bilirubin (<i>n</i> = 7, 21.9%), SGPT (<i>n</i> = 6, 18.8%), and SGOT (<i>n</i> = 5, 15.6%). A higher proportion of this group (<i>n</i> = 20, 62.5%) presented with Fuhrman’s grade 3 &amp; 4 compared to patients without Stauffer syndrome (<i>n</i> = 64, 40%). The five-year survival rate for Stauffer syndrome patients was 89.3% (95% CI: 70 to 96.4%), a little higher than patients without Stauffer syndrome (80.1%; 95% CI: 71.5 to 86.3%), though statically not significant (hazard ratio: 0.47; 95% CI: 0.13 to 1.65, <i>p</i> = 0.24). Stauffer syndrome is a notable paraneoplastic condition in RCC, crucial for pre-operative diagnosis due to its prognostic implications. Further multi-centric studies are needed to improve the evidence quality.</p>