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<p>Hepatocellular carcinoma (HCC) presenting as calvarial metastasis (CM) is a rare situation with limited reports in literature. We present a case of a 64-year-old gentleman, who presented with an 8-month history of swelling on the right forehead, associated with decreased vision and size of the right eye. Magnetic resonance imaging revealed a partially hemorrhagic lesion in the right frontal bone, extending into the scalp and causing a midline shift, with intra-orbital and intraconal extension. Positron emission tomography showed multiple bi-lobar liver metastases. The patient was diagnosed with hepatitis B–associated hepatocellular carcinoma on biopsy and was started on dexamethasone, anti-epileptic prophylaxis, and Lenvatinib. He also received focal radiotherapy for the CM. Advanced imaging techniques were crucial in diagnosing the disease’s extent. The patient’s management, involving pharmacological therapy, radiotherapy, and supportive care, highlights the need for a multidisciplinary approach in treating advanced malignancies.</p>

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Calvarial Metastasis as the Initial Presentation in Hepatocellular Carcinoma: A Rare Entity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月19日

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  • Katyayani Kumari,
  • Abdeali Saif Arif Kaderi,
  • Shraddha Patkar

摘要

Hepatocellular carcinoma (HCC) presenting as calvarial metastasis (CM) is a rare situation with limited reports in literature. We present a case of a 64-year-old gentleman, who presented with an 8-month history of swelling on the right forehead, associated with decreased vision and size of the right eye. Magnetic resonance imaging revealed a partially hemorrhagic lesion in the right frontal bone, extending into the scalp and causing a midline shift, with intra-orbital and intraconal extension. Positron emission tomography showed multiple bi-lobar liver metastases. The patient was diagnosed with hepatitis B–associated hepatocellular carcinoma on biopsy and was started on dexamethasone, anti-epileptic prophylaxis, and Lenvatinib. He also received focal radiotherapy for the CM. Advanced imaging techniques were crucial in diagnosing the disease’s extent. The patient’s management, involving pharmacological therapy, radiotherapy, and supportive care, highlights the need for a multidisciplinary approach in treating advanced malignancies.