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<p>Granular cell tumors (GCT) are rare, mostly benign tumors originating from the neural sheath, with a higher prevalence in the head and neck region. This research aimed to characterize the clinical and pathological patterns of GCT presented to a tertiary care center in central Kerala, India, and to evaluate recurrence rates in this cohort over a 54.4-month follow-up period. Over the span of 8 years, 36 cases of granular cell tumors were diagnosed, with 52.8% of the patients being female. The mean age at presentation was 43 years (SD ± 18.1 years). The head and neck were the most common region of occurrence (43.75%), with the tongue being the most frequently affected site. The mean tumor size was 1.49 cm (SD ± 0.78 cm). All cases were diagnosed as benign GCTs. Among the 14 patients who were followed up, no recurrences were observed, regardless of whether their surgical margins were positive or negative.</p>

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Clinicopathological Profile and Recurrence Pattern of Granular Cell Tumor Cases in a Tertiary Center in Central Kerala

  • 期刊论文

  • 发表日期：

    2025年4月24日

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  • Anju C. K.,
  • Murali T. V.,
  • Jose V. Stanley,
  • Sansho E. U.,
  • Milu Elizabeth Cyriac,
  • Letha V.

摘要

Granular cell tumors (GCT) are rare, mostly benign tumors originating from the neural sheath, with a higher prevalence in the head and neck region. This research aimed to characterize the clinical and pathological patterns of GCT presented to a tertiary care center in central Kerala, India, and to evaluate recurrence rates in this cohort over a 54.4-month follow-up period. Over the span of 8 years, 36 cases of granular cell tumors were diagnosed, with 52.8% of the patients being female. The mean age at presentation was 43 years (SD ± 18.1 years). The head and neck were the most common region of occurrence (43.75%), with the tongue being the most frequently affected site. The mean tumor size was 1.49 cm (SD ± 0.78 cm). All cases were diagnosed as benign GCTs. Among the 14 patients who were followed up, no recurrences were observed, regardless of whether their surgical margins were positive or negative.