Aim <p>To find the association between cholecystectomy and colorectal cancer.</p> Methodology <p>This is a case control study which consisted of 138 cases and 140 controls. This study was conducted with the ethical approval of the ethics committee and has also received the ICMR STS grant. Data of 138 patients who were diagnosed with colorectal cancer in the last 5&#xa0;years were analyzed for a history of cholecystectomy. Those who developed colorectal cancer within a year of their cholecystectomy were excluded from the study to minimize protopathic bias. The control group was composed of healthy individuals. Data extracted was organized in Microsoft Excel and was analyzed about the main objective. Chi-square test was used to find the association between cholecystectomy and colorectal cancer.</p> Results <p>The percentage of cholecystectomy in the colorectal cancer group was 6.5% vs 2.1% in the control group (<i>P</i> value = 0.072). There were no statistically significant associations between diabetes, hypertension, CKD, alcohol intake or smoking, and the incidence of colorectal cancer.</p> Conclusion <p>Based on our study, there is no evidence to support an association between colorectal cancer and cholecystectomy.</p>