<p>The celiac trunk and portal vein and are the main sources of blood supply to the pancreas. The vascular system is highly variable, and in pathological scenarios, certain alterations may take place to compensate for its deficiencies. Data from a patient with pancreatic cancer who had an uncommon anatomical variant of the celiac trunk and a compensatory portal vein transformation were examined. Contrast computed tomography of the abdomen revealed the cause of jaundice and abdominal bloating. The mass was found located at the head and neck of pancreas, obstructing the common bile duct and causing jaundice. It was revealed that the splenic artery emerges directly from the aorta abdominalis on the same plane, as the common trunk of the common hepatic artery and left gastric artery. Due to portal vein occlusion, the portal vein underwent compensatory remodeling in the interim to restore blood flow. The complexity of the blood vessels makes subsequent treatments more difficult for this patient. Understanding these variations is crucial for surgical and interventional procedures.</p>