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<p>Ki-67 is a protein expressed in the nucleus of cells during different phases of the cell cycle. Higher levels of Ki-67 expression in breast cancer are associated with high proliferation and poor prognosis. Neutrophil-to-lymphocyte ratio (NLR) is a peripheral marker of inflammation, an elevated pretreatment NLR is associated with an increased risk of relapse and worse survival among breast cancer patients. The present study was a retrospective and prospective study conducted on 140 patients under which the presurgical neutrophil–lymphocyte ratio was correlated with histological subtype, grade, stage, molecular subtype, and Ki-67 proliferation index in patients with breast carcinoma. There was a significant association between Ki67 expression groups and NLR ratio as well as between molecular subtypes groups and NLR ratio (<i>p</i> &lt; 0.001). However, no significant association was found between Nottingham Bloom Richardson (NBR) grades and tumor size, nodal status, and metastasis (TNM) stages with NLR ratio (<i>p</i> &gt; 0.001). NLR is a low-cost, minimally invasive, personal, and reliable marker of inflammation which has potential utility in predicting short- and long-term prognosis and risk stratification for anti-inflammatory or immune therapy for cancer patients in the future.</p>

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Correlation of Peripheral Neutrophil-to-Lymphocyte Ratio (NLR) with Ki-67 and Other Clinicopathological Parameters of Breast Carcinoma

  • 期刊论文

  • 发表日期：

    2025年1月14日

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  • Priti Mishra,
  • Aparna Bhardwaj,
  • Saqib Ahmed

摘要

Ki-67 is a protein expressed in the nucleus of cells during different phases of the cell cycle. Higher levels of Ki-67 expression in breast cancer are associated with high proliferation and poor prognosis. Neutrophil-to-lymphocyte ratio (NLR) is a peripheral marker of inflammation, an elevated pretreatment NLR is associated with an increased risk of relapse and worse survival among breast cancer patients. The present study was a retrospective and prospective study conducted on 140 patients under which the presurgical neutrophil–lymphocyte ratio was correlated with histological subtype, grade, stage, molecular subtype, and Ki-67 proliferation index in patients with breast carcinoma. There was a significant association between Ki67 expression groups and NLR ratio as well as between molecular subtypes groups and NLR ratio (p < 0.001). However, no significant association was found between Nottingham Bloom Richardson (NBR) grades and tumor size, nodal status, and metastasis (TNM) stages with NLR ratio (p > 0.001). NLR is a low-cost, minimally invasive, personal, and reliable marker of inflammation which has potential utility in predicting short- and long-term prognosis and risk stratification for anti-inflammatory or immune therapy for cancer patients in the future.