Primary Neuroendocrine Carcinoma of Breast: Changing Paradigm

Neuroendocrine carcinomas are one of the most rare malignancies of the breast. Theoretically they can arise from any organ of the body, but incidence in breast is very rare. Due to the ever-changing definition of the disease, no specific therapeutic guideline is available in current literature. Currently WHO defines neuroendocrine carcinoma of breast as malignant lesions that expresses > 90% of neuroendocrine markers like synaptophysin, chromogranin A with characteristic histopathology features with exclusion of solid papillary carcinoma, and hypercellular-type mucinous carcinoma.