<p>Cancer disproportionately impacts low- and middle-income countries (LMICs), where 70% of cancer-related deaths occur. Oncology providers are needed in global health, but significant barriers limit participation. This study explores challenges impacting global oncology engagement among cancer-oriented trainees and faculty at an academic medical center with strengths in global health and cancer care. A cross-sectional survey was distributed to residents, fellows, and faculty in oncology and oncology-related specialties between May and November 2025. The 33-question survey assessed demographics, prior oncology and global health experiences, interests and barriers impacting participation, and institutional support. Descriptive analysis was performed. There were 46 and 45 eligible responses from trainees and faculty, respectively. Only 16 (34.8%) trainees and 25 faculty (55.6%) knew about global oncology, with only four trainees (8.7%) having prior experience. Most trainees (80.4%) and faculty (80%) expressed interest in learning more and participating. However, scheduling conflicts and limited funding prevented engagement, along with absent mentorship for trainees and family obligations for faculty. Most trainees felt global oncology involvement would build their cross-cultural competence (73.9%) and strengthen clinical knowledge and research skills (65.2%). However, only 8.7% felt that current institutional support was adequate (8.7%). Significant interest in global oncology exists among trainees and faculty, but limited prior exposure, along with absent funding, time, and institutional support, limit engagement. Expanding structured training opportunities and institutional investment could motivate increased global oncology involvement and train more oncology leaders to address cancer disparities globally.</p>