Introduction <p>Many studies have shown that policies can have significant effects on the lives of transgender (trans) people. Supportive policies have been found to have positive effects on trans people’s mental well-being. A previous study by the authors found that these effects differ by whether trans people used hormones as part of their gender transition in a large convenience sample of trans people. This study aims to replicate the previous study using a probability sample of trans individuals.</p> Methods <p>This study utilizes data from the Transpop Study, the first national probability sample of trans individuals. Data were collected during two periods (April 2016–August 2016 and June 2017–December 2018) and consist of a sample of 274 trans individuals.</p> Results <p>The study’s analysis found that non-hormone using trans people living in states with supportive policies reported less distress than non-hormone using trans people in non-supportive states. Policies did not impact the distress experienced by hormone-using trans people. Among social variables, only social well-being, a measure of one’s connection to a larger society, was associated with less distress for both hormone and non-hormone using trans people. Experiences of discrimination for both groups were associated with more distress.</p> Conclusions <p>The current study, using a probability sample of trans people, was able to replicate the findings of an earlier study that used a large convenience sample of trans people. The implication is that trans people can have different social experiences and respond to policy changes differently.</p> Policy Implications <p>The study reaffirms that trans people’s use of gender affirming care can affect the relationship between policy and distress. This highlights the need to view trans populations as a diverse group and the importance of gender affirming care in their lives.&#xa0;</p>