Introduction <p>Social stigma negatively impacts achievement across social settings and behavioral health for LGB + college students. It is vital to identify resilience factors malleable to intervention to support the population’s wellbeing. We explored grit as an individual resilience factor relative to social support and psychological distress among a sample of college students.</p> Methods <p>LGB + (<i>n</i> = 58) and heterosexual (<i>n</i> = 282) undergraduate students at one public university completed an online survey in the Fall of 2020. Participants self-reported grit, psychological distress, social support, and demographics. Bivariate (chi-square, <i>t</i>-tests, correlation) and multivariable analyses (multivariable linear regression) were used to examine associations among variables.</p> Results <p>LGB + participants had significantly lower grit scores than heterosexual students. Among the LGB + subsample, grit had a significant inverse relationship to psychological distress while social support from a college friend predicted higher grit scores.</p> Conclusion <p>These findings show that grit may serve as a protective factor against psychological distress for LGB+ college students, with social support from college friends playing a role in fostering this resilience. Interventions targeting social connection and peer support networks could potentially enhance grit and reduce psychological distress among LGB+ students on college campuses.</p> Policy Implications <p>Campus policies should support prevention and intervention efforts to increase grit among LGB + college students by focusing on increasing social support, which may reduce psychological distress in turn.</p>