Introduction <p>Recent advancements in legislation have enhanced the availability of parental opportunities for lesbian, gay, and bisexual (LGB) individuals. Consequently, policy makers and mental health professionals may aid LGB individuals who confront the decision of becoming parents. The present study examined how sexual orientation, anticipation of stigma upon parenthood, and the personality trait of openness to experience (characterized by curiosity and receptiveness to new stimuli) contribute to parenthood aspirations of LGB individuals.</p> Methods <p>The study included 314 LGB and 392 heterosexual participants aged 18–49 who completed online questionnaires between November 2022 and July 2023 on their parenthood aspirations, anticipation of stigma upon parenthood, and openness to experience.</p> Results <p>Indirect-effect analyses revealed that LGB individuals reported lower parenthood aspirations than heterosexual individuals. Moreover, an indirect effect was evident for sexual orientation on parenthood aspirations through anticipation of stigma upon parenthood, such that, relative to heterosexuals, LGB individuals reported greater anticipation of stigma upon parenthood, which, in turn, was associated with lower levels of parenthood aspirations. Lastly, conditional PROCESS analyses showed that higher levels of openness to experience weakened this indirect effect.</p> Conclusions <p>These findings revealed the co-existing vulnerability and resilience factors among LGB individuals considering parenthood, such that openness to experience mitigated potential negative consequences of expected parenthood-related stigma.</p> Policy Implications <p>Policy makers and social agents should promote an accepting atmosphere toward parenthood possibilities of sexual minorities. Moreover, mental health professionals and researchers should recognize the unique processes underlying parenthood aspirations among sexual minorities to provide them with sensitive care.</p>