Scholarlink

Objective <p>Although antihypertensive medication is central to hypertension management, substantial residual risks persist. This study evaluated the associations of healthy lifestyle behaviors with all-cause mortality and cardiovascular disease (CVD) among individuals with hypertension, and assessed whether favorable lifestyles provided additional benefits beyond antihypertensive medication. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that comprehensive lifestyle assessment could refine risk stratification and help identify priority targets.</p> Methods <p>This study included 16,314 participants with hypertension from the Prospective Urban Rural Epidemiology (PURE)-China study. A healthy lifestyle score (0–6, higher scores indicating healthier behaviors) was constructed based on six lifestyle behaviors. Antihypertensive medication use was defined as regular intake at least once per week. Cox frailty models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).</p> Results <p>During a median follow-up of 11.9 years, 1,423 deaths and 2,418 CVD events occurred. Compared with the high score group (5–6), participants in the low score group (0–2) had higher risks of all-cause mortality (HR: 1.77, 95% CI 1.42–2.20) and CVD (HR: 1.56, 95% CI 1.28–1.89). Diet emerged as the strongest lifestyle predictor based on explained relative risk (<i>R²</i>). Healthier lifestyles reduced all-cause mortality regardless of medication use, while an unfavorable lifestyle increased CVD risk among medication users.</p> Conclusions <p>Among individuals with hypertension, healthier lifestyles were associated with lower risks of all-cause mortality and CVD, independent of antihypertensive medication. Integrating lifestyle assessment into hypertension management may reduce risk in line with the PPPM/3PM framework.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The interplay between antihypertensive medication and lifestyle with cardiovascular outcomes in patients with hypertension: the PURE-China study

  • 期刊论文

  • 发表日期：

    2026年2月26日

查看全文
  • Biyan Wang,
  • Zhiguang Liu,
  • Tong Bu,
  • Sumathy Rangarajan,
  • Qiuyan Ma,
  • Xiaocong Li,
  • Qi Qiu,
  • Yang Lin,
  • Lap Ah Tse,
  • Bo Hu,
  • Salim Yusuf,
  • Qiujing Cai,
  • Wei Li,
  • Lisheng Liu,
  • Jun Zhu,
  • Guoliang Han,
  • Liya Xie,
  • Chuangshi Wang,
  • Mengya Li,
  • Yang Li,
  • Qing Deng,
  • Yan Liang,
  • Yanjie Xia,
  • Jun Hao,
  • Xinyue Lang,
  • Xin Liu,
  • Mengxin Chen,
  • Duoer Wang,
  • Chilie Danzeng,
  • Yilin Huang,
  • Qi Li,
  • Minghai Yan,
  • Yi Sun,
  • Xiaoyun Liu,
  • Hongye Zhang,
  • Xingyu Wang,
  • Sidong Li,
  • Weida Liu,
  • Yang Wang,
  • Xuan Jia,
  • Xinye He,
  • Xiaoru Cheng,
  • Fanghong Lu,
  • Kai You,
  • Yan Hou,
  • Liangqing Zhang,
  • Baoxia Guo,
  • Xiaoyang Liao,
  • Di Chen,
  • Peng Zhang,
  • Ning Li,
  • Xiaolan Ma,
  • Rensheng Lei,
  • Minfan Fu,
  • Yu Liu,
  • Xiaojie Xing,
  • Yuanting Ma,
  • Guomin He,
  • Quanyong Xiang,
  • Jinhua Tang,
  • Zhengrong Liu,
  • Deren Qiang,
  • Aiying Han,
  • Aideeraili Ayoupu,
  • Qian Zhao

摘要

Objective

Although antihypertensive medication is central to hypertension management, substantial residual risks persist. This study evaluated the associations of healthy lifestyle behaviors with all-cause mortality and cardiovascular disease (CVD) among individuals with hypertension, and assessed whether favorable lifestyles provided additional benefits beyond antihypertensive medication. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that comprehensive lifestyle assessment could refine risk stratification and help identify priority targets.

Methods

This study included 16,314 participants with hypertension from the Prospective Urban Rural Epidemiology (PURE)-China study. A healthy lifestyle score (0–6, higher scores indicating healthier behaviors) was constructed based on six lifestyle behaviors. Antihypertensive medication use was defined as regular intake at least once per week. Cox frailty models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

During a median follow-up of 11.9 years, 1,423 deaths and 2,418 CVD events occurred. Compared with the high score group (5–6), participants in the low score group (0–2) had higher risks of all-cause mortality (HR: 1.77, 95% CI 1.42–2.20) and CVD (HR: 1.56, 95% CI 1.28–1.89). Diet emerged as the strongest lifestyle predictor based on explained relative risk (R²). Healthier lifestyles reduced all-cause mortality regardless of medication use, while an unfavorable lifestyle increased CVD risk among medication users.

Conclusions

Among individuals with hypertension, healthier lifestyles were associated with lower risks of all-cause mortality and CVD, independent of antihypertensive medication. Integrating lifestyle assessment into hypertension management may reduce risk in line with the PPPM/3PM framework.