Scholarlink

<p>Over the past two decades, significant progress has been made in the study of minimal residual disease (MRD) in patients with solid tumors. Increasing evidence supports that monitoring and quantifying MRD can provide prognostic insights and enable personalized treatment strategies for patients who achieve complete remission. Although MRD is gradually being integrated into the clinical management of solid tumors, several challenges remain unresolved. This review combines bibliometric analysis with advances in cutting-edge technologies to examine the evolving landscape of MRD, emphasizing its alignment with the predictive, preventive, and personalized medicine (PPPM/3PM) paradigm. By synthesizing research trends, key challenges, and innovative approaches, we highlight the predictive value of MRD for relapse risk, its preventive role in early intervention, and its potential to guide real-time personalized therapies. We advocate for the standardization and integration of MRD monitoring into routine clinical oncology practice, reinforced by expert recommendations grounded in 3PM principles.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The 3PM transformation potential of minimal residual disease in solid tumor management: a bibliometric analysis and review

  • 期刊论文

  • 发表日期：

    2025年5月26日

查看全文
  • Yining Chen,
  • Xin Li,
  • Suya Zhao,
  • Yuchong Zhang,
  • Haixu Wang,
  • Fangjian Na,
  • Qi Guan,
  • Zhi Li,
  • Heming Li,
  • Mingfang Zhao

摘要

Over the past two decades, significant progress has been made in the study of minimal residual disease (MRD) in patients with solid tumors. Increasing evidence supports that monitoring and quantifying MRD can provide prognostic insights and enable personalized treatment strategies for patients who achieve complete remission. Although MRD is gradually being integrated into the clinical management of solid tumors, several challenges remain unresolved. This review combines bibliometric analysis with advances in cutting-edge technologies to examine the evolving landscape of MRD, emphasizing its alignment with the predictive, preventive, and personalized medicine (PPPM/3PM) paradigm. By synthesizing research trends, key challenges, and innovative approaches, we highlight the predictive value of MRD for relapse risk, its preventive role in early intervention, and its potential to guide real-time personalized therapies. We advocate for the standardization and integration of MRD monitoring into routine clinical oncology practice, reinforced by expert recommendations grounded in 3PM principles.