We discuss the self-adjointness in \(L^2\) -setting of the operators acting as \(-\nabla \cdot h\nabla \) , with piecewise constant functions h having a jump along a Lipschitz hypersurface \(\Sigma \) , without explicit assumptions on the sign of h. We establish a number of sufficient conditions for the self-adjointness of the operator with \(H^s\) -regularity for suitable \(s\in [1,\frac{3}{2}]\) , in terms of the jump value and the regularity and geometric properties of \(\Sigma \) . An important intermediate step is a link with Fredholm properties of the Neumann-Poincaré operator on \(\Sigma \) , which is new for the Lipschitz setting.