<p>A large scale of reservoirs are developed along strike-slip fault damage zone in the transition area between Awati and Mangar depressions (Aman transition zone) in Tarim Basin. These reservoirs are becoming important targets for oil and gas exploration and development in the abdomen of the Tarim basin, and also a hot spot in the study of fault damage zone controlling-reservoir accumulation in the Tarim basin in recent years. Based geology, seismic, and geochemistry data with a tripartite methodology (lithofacies analysis, structural deformation, and karstification), this paper analyzes the formation and filling-reformed processes of reservoirs, and their internal relationship with strike-slip faulting and karstification in Aman transition zone. The research shows that: (1) The study identifies three main types of fillings and at least four stages of filling period in Aman transition zone. It elucidates the mechanisms of early meteoric freshwater filling and subsequent hydrothermal filling, as well as their bidirectional reconstruction effects on the reservoirs. (2) A sequence for the formation and evolution of reservoirs in the Aman transition zone is established. It is proposed that the reservoirs primarily formed during the middle to late Ordovician period, characterized by intense coupling of faulting and karstification. The study reveals the planar zonation and vertical stratification patterns of the reservoirs. (3) The primary controlling factors for the differential distribution of reservoirs along strike-slip fault zones are clarified. The study reveals the “facies-fault-karst” ternary spatiotemporal differential coupling mechanism for reservoir control in the Aman transition zone. The research findings provide significant scientific evidence for the fundamental geological studies of ultra-deep carbonate hydrocarbon reservoirs.</p>