<p>This study focuses on a typical demonstration area for soil and water loss prevention and control in northern Guangxi. Polyacrylamide (PAM) solution was applied to the soil surface layer to investigate its effects on soil and water loss control under different application rates and slopes. Artificial rainfall simulation was used to explore soil loss under different PAM solution concentrations, slopes, and fissure degrees. The results indicate the following: Under constant rainfall intensity and subsurface fissure degree, when the amount of PAM solution applied to the surface layer of red clay slope is 1–3&#xa0;g/m², more large aggregates are produced. These aggregates are effective in resisting raindrop impact and inhibiting soil crusting, thus effectively reducing soil loss. Moreover, at this concentration, there are fewer PAM molecules in the runoff, resulting in less "artificial crust" formation, which has a smaller impact on the soil and leads to better treatment effects. When the slope is 0–3°, the component force of soil gravity and runoff erosion along the slope is small. It is difficult to wash away the natural crust and "artificial crust" into the runoff, which can effectively reduce soil erosion and thus reduce soil and water loss. Under this concentration and slope, soil loss decreases with the increase of fissure degree. This study can provide theoretical guidance and technical support for the prevention and control of soil and water loss in karst rocky mountain areas.</p>