Scholarlink

Objective <p>PSMA PET/CT has a comparable accuracy to multiparametric MRI for detecting intra-prostatic lesions. However, data are limited regarding the value of uptake intensity and modified PRIMARY-like score using <sup>99m</sup>Tc-HYNIC-PSMA-11 SPECT/CT for localization of the intra-prostatic tumor, correlated with trans-rectal ultrasonography-guided (TRUS) biopsy histopathological findings.</p> Patients and Methods <p>In this retrospective study, <sup>99m</sup>Tc-HYNIC-PSMA-11 SPECT/CT scans of 97 treatment-naïve patients referred for staging were assessed in a blinded manner. The tumor-to-liver ratio (TLR) was calculated as the highest prostate tumoral uptake relative to the liver, and, for each patient, a modified PRIMARY-like score was reported. Each prostate gland was divided into six sextants according to the miTNM criteria, and the readers were asked to indicate whether the tumor involved each sextant. The results of the systematic biopsy were correlated with the scan results. </p> Results <p>The patients had a mean age of 67.0 ± 7.3 years and a PSA level of 24.4 ± 25.6. Of the 582 evaluated sextants, 354 (60.8%) were reported as cancerous on pathology and 324 (55.7%) as PRIMARY-positive (score &gt;2) on scan. Regarding ISUP grade group (GG) ≥1, ≥3, and ≥4, the reader’s accuracy did not change significantly (63.6%, 69.1%, and 58.9%, respectively). The best AUC achieved for TLR, and the modified PRIMARY-like score was 0.864 and 0.784 for the prediction of ISUP ≥2, respectively.</p> Conclusion <p>The best discriminatory thresholds for TLR and modified PRIMARY-like score using <sup>99m</sup>Tc-HYNIC-PSMA-11 SPECT/CT are achieved when differentiating ISUP GG 1 from ≥2. Overall, 99mTc-HYNIC-PSMA-11 SPECT/CT can be a valuable diagnostic option for patients with newly diagnosed prostate cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Can 99mTc-HYNIC-PSMA-11 SPECT/CT Localize the Intra-prostatic Tumor? A Single-Center Study

  • 期刊论文

  • 发表日期：

    2026年6月24日

查看全文
  • Sajjad Sadeghpour,
  • Sobhan Javidi,
  • Alireza Gholami,
  • Amirali Pourtajoddini,
  • Fateme Taheri,
  • Amin Saber Tanha,
  • Behzad Aminzadeh,
  • Lida Jarahi,
  • Atena Aghaee,
  • Mahmoud Kalantari,
  • Emran Askari

摘要

Objective

PSMA PET/CT has a comparable accuracy to multiparametric MRI for detecting intra-prostatic lesions. However, data are limited regarding the value of uptake intensity and modified PRIMARY-like score using 99mTc-HYNIC-PSMA-11 SPECT/CT for localization of the intra-prostatic tumor, correlated with trans-rectal ultrasonography-guided (TRUS) biopsy histopathological findings.

Patients and Methods

In this retrospective study, 99mTc-HYNIC-PSMA-11 SPECT/CT scans of 97 treatment-naïve patients referred for staging were assessed in a blinded manner. The tumor-to-liver ratio (TLR) was calculated as the highest prostate tumoral uptake relative to the liver, and, for each patient, a modified PRIMARY-like score was reported. Each prostate gland was divided into six sextants according to the miTNM criteria, and the readers were asked to indicate whether the tumor involved each sextant. The results of the systematic biopsy were correlated with the scan results.

Results

The patients had a mean age of 67.0 ± 7.3 years and a PSA level of 24.4 ± 25.6. Of the 582 evaluated sextants, 354 (60.8%) were reported as cancerous on pathology and 324 (55.7%) as PRIMARY-positive (score >2) on scan. Regarding ISUP grade group (GG) ≥1, ≥3, and ≥4, the reader’s accuracy did not change significantly (63.6%, 69.1%, and 58.9%, respectively). The best AUC achieved for TLR, and the modified PRIMARY-like score was 0.864 and 0.784 for the prediction of ISUP ≥2, respectively.

Conclusion

The best discriminatory thresholds for TLR and modified PRIMARY-like score using 99mTc-HYNIC-PSMA-11 SPECT/CT are achieved when differentiating ISUP GG 1 from ≥2. Overall, 99mTc-HYNIC-PSMA-11 SPECT/CT can be a valuable diagnostic option for patients with newly diagnosed prostate cancer.