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<p>A 43-year-old male with progressive musculoskeletal pain and recurrent fractures was misdiagnosed with ankylosing spondylitis due to HLA-B27 positivity. Metabolic evaluation confirmed tumor-induced osteomalacia (TIO). [68&#xa0;Ga]Ga-DOTATATE PET/CT localized the culprit lesion to a right iliac mass (SUV max 26.6), distinguishing it from multiple insufficiency fractures exhibiting only faint uptake. Histopathology confirmed a rare giant cell tumor of soft tissue. Following excision, phosphate levels normalized with significant functional recovery. This case underscores the specificity of [68&#xa0;Ga]Ga-DOTATATE in TIO and warns against diagnostic "red herrings" like incidental HLA-B27.</p>

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[68 Ga]Ga-DOTATATE in Identifying Giant Cell Tumor Causing Tumor-Induced Osteomalacia

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Mai Hong Son,
  • Nguyen Quang Huy,
  • Mai Huy Thong,
  • Pham Thi Minh Nham,
  • Tran Thi Lan,
  • Riccardo Mei,
  • Akram Al-Ibraheem

摘要

A 43-year-old male with progressive musculoskeletal pain and recurrent fractures was misdiagnosed with ankylosing spondylitis due to HLA-B27 positivity. Metabolic evaluation confirmed tumor-induced osteomalacia (TIO). [68 Ga]Ga-DOTATATE PET/CT localized the culprit lesion to a right iliac mass (SUV max 26.6), distinguishing it from multiple insufficiency fractures exhibiting only faint uptake. Histopathology confirmed a rare giant cell tumor of soft tissue. Following excision, phosphate levels normalized with significant functional recovery. This case underscores the specificity of [68 Ga]Ga-DOTATATE in TIO and warns against diagnostic "red herrings" like incidental HLA-B27.