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Background <p>This study aimed to evaluate the impact of Enhanced External Counterpulsation (EECP) therapy on myocardial blood flow (MBF) during stress and rest conditions, as well as coronary flow reserve (CFR). These parameters were assessed using non-invasive oxygen-15–labeled water ([<sup>15</sup>O]H<sub>2</sub>O) positron emission tomography/computed tomography (PET/CT) myocardial perfusion imaging (MPI).</p> Methods <p>Seven patients (six male, mean age 61.67 ± 9.33 years) with coronary artery disease completed 35 sessions of EECP therapy. All patients underwent [<sup>15</sup>O]H<sub>2</sub>O PET/CT MPI during rest and adenosine-induced stress conditions before and after EECP treatment, within a one-month period. MBF and CFR were measured, and a paired t-test was used to evaluate the significance of EECP’s effects (<i>p</i> &lt; 0.05).</p> Results <p>In a per-patient analysis, one patient had a normal [<sup>15</sup>O] H<sub>2</sub>O PET/CT MPI study, while six had abnormal scans at pre-EECP, with no changes post-EECP. However, significant increases in stress MBF were observed per vascular territories (<i>p</i> = 0.023) and within the 17-segment model (<i>p</i> = 0.002) following EECP. Subgroup analysis showed a significant rise in stress MBF in segments with initially low stress MBF (<i>p</i> = 0.002) and in rest MBF in segments with normal pre-EECP stress MBF (<i>p</i> = 0.001). CFR increased significantly in segments with initially abnormal CFR (<i>p</i> = 0.0003) and decreased in segments with normal CFR (<i>p</i> = 0.007).</p> Conclusion <p>In our small study group, EECP significantly improved MBF and CFR, particularly in stress-induced regions with significant CAD, as confirmed by [<sup>15</sup>O]H<sub>2</sub>O PET/CT MPI.</p>

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Improved Stress Myocardial Blood Flow in Patients Receiving Enhanced External Counter Pulsation (EECP) Therapy Measured by [15O]H2O PET/CT: Pilot Study

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Anchisa Kunawudhi,
  • Attapon Jantarato,
  • Peerapon Kiatkittikul,
  • Dheeratama Siripongsatian,
  • Natphimol Boonkawin,
  • Phornpa Lertutsahakul,
  • Sunida Khamjit,
  • Chanisa Chotipanich,
  • Chetsadaporn Promteangtrong

摘要

Background

This study aimed to evaluate the impact of Enhanced External Counterpulsation (EECP) therapy on myocardial blood flow (MBF) during stress and rest conditions, as well as coronary flow reserve (CFR). These parameters were assessed using non-invasive oxygen-15–labeled water ([15O]H2O) positron emission tomography/computed tomography (PET/CT) myocardial perfusion imaging (MPI).

Methods

Seven patients (six male, mean age 61.67 ± 9.33 years) with coronary artery disease completed 35 sessions of EECP therapy. All patients underwent [15O]H2O PET/CT MPI during rest and adenosine-induced stress conditions before and after EECP treatment, within a one-month period. MBF and CFR were measured, and a paired t-test was used to evaluate the significance of EECP’s effects (p < 0.05).

Results

In a per-patient analysis, one patient had a normal [15O] H2O PET/CT MPI study, while six had abnormal scans at pre-EECP, with no changes post-EECP. However, significant increases in stress MBF were observed per vascular territories (p = 0.023) and within the 17-segment model (p = 0.002) following EECP. Subgroup analysis showed a significant rise in stress MBF in segments with initially low stress MBF (p = 0.002) and in rest MBF in segments with normal pre-EECP stress MBF (p = 0.001). CFR increased significantly in segments with initially abnormal CFR (p = 0.0003) and decreased in segments with normal CFR (p = 0.007).

Conclusion

In our small study group, EECP significantly improved MBF and CFR, particularly in stress-induced regions with significant CAD, as confirmed by [15O]H2O PET/CT MPI.