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Purpose <p>This study evaluated the comparative performance of standardized uptake value (SUV) measurements derived from positron emission tomography/magnetic resonance imaging (PET/MRI) and digital positron emission tomography/computed tomography (PET/CT) in lymphoma patients. A retrospective analysis was conducted to compare semi-quantitative measures and assess the correlation and concordance between the two imaging modalities.</p> Methods <p>A total of 106 lymphoma patients underwent both PET/CT and PET/MRI, either in the order of PET/CT followed by PET/MRI (PET/CT<sub>first</sub> group, <i>n</i> = 51) or PET/MRI followed by PET/CT (PET/MRI<sub>first</sub> group, <i>n</i> = 55). SUV measurements in lesions, liver, and mediastinal blood pool were compared between modalities.</p> Results <p>SUV<sub>max</sub> and SUV<sub>mean</sub> were significantly lower in PET/MRI than PET/CT (<i>P</i> &lt; 0.001), except SUV<sub>mean</sub> for mediastinal blood pool in the PET/MRI<sub>first</sub> group (<i>P</i> = 0.090). Correlation between modalities was very high for the lesions (ρ = 0.90–0.96). The Deauville five-point scale (D5PS) scores had good agreement between modalities (κ = 0.6566 for PET/CT<sub>first</sub> and κ = 0.4846 for PET/MRI<sub>first</sub>; <i>P</i> &lt; 0.001), but the response categorization would have been different in 22/262 PET/CT<sub>first</sub> group and 21/155 PET/MR<sub>first</sub> group.</p> Conclusion <p>SUV measurements from PET/MRI demonstrated strong correlation and good agreement in D5PS classification compared to digital PET/CT. Nonetheless, variations in PET subsystem technologies across modalities may influence quantitative values, and such differences should be carefully considered when interpreting results.</p>

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Comparison of Semi-Quantitative Parameters of 18F-FDG Digital PET/CT and Simultaneous PET/MRI in Lymphoma Patients

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Pimlapat Panperee,
  • Supachoke Thongdonpua,
  • Attapon Jantarato,
  • Chetsadaporn Promteangtrong,
  • Anchisa Kunawudhi,
  • Peerapon Kiatkittikul,
  • Dheeratama Siripongsatian,
  • Jiratthakorn Keeratipiriyakul,
  • Onanong Konggasame,
  • Chanisa Chotipanich

摘要

Purpose

This study evaluated the comparative performance of standardized uptake value (SUV) measurements derived from positron emission tomography/magnetic resonance imaging (PET/MRI) and digital positron emission tomography/computed tomography (PET/CT) in lymphoma patients. A retrospective analysis was conducted to compare semi-quantitative measures and assess the correlation and concordance between the two imaging modalities.

Methods

A total of 106 lymphoma patients underwent both PET/CT and PET/MRI, either in the order of PET/CT followed by PET/MRI (PET/CTfirst group, n = 51) or PET/MRI followed by PET/CT (PET/MRIfirst group, n = 55). SUV measurements in lesions, liver, and mediastinal blood pool were compared between modalities.

Results

SUVmax and SUVmean were significantly lower in PET/MRI than PET/CT (P < 0.001), except SUVmean for mediastinal blood pool in the PET/MRIfirst group (P = 0.090). Correlation between modalities was very high for the lesions (ρ = 0.90–0.96). The Deauville five-point scale (D5PS) scores had good agreement between modalities (κ = 0.6566 for PET/CTfirst and κ = 0.4846 for PET/MRIfirst; P < 0.001), but the response categorization would have been different in 22/262 PET/CTfirst group and 21/155 PET/MRfirst group.

Conclusion

SUV measurements from PET/MRI demonstrated strong correlation and good agreement in D5PS classification compared to digital PET/CT. Nonetheless, variations in PET subsystem technologies across modalities may influence quantitative values, and such differences should be carefully considered when interpreting results.