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Purpose <p>Neuroendocrine tumors (NETs) can be classified into three grades based on the malignancy index identified via histological and pathological diagnosis, and <sup>111</sup>In-pentetreotide single photon emission computed tomography (SPECT) is effective for diagnosis. Therefore, this study aimed to distinguish between NET grade 1 (G1) and NET grade 2 (G2) based on the change in standardized uptake value (SUV) 4 and 24&#xa0;h after injection in pancreatic and gastrointestinal NETs.</p> Methods <p>Twenty-two patients underwent <sup>111</sup>In-pentetreotide SPECT and were definitively diagnosed with pancreatic or gastrointestinal NETs. The volume of interest were set in the tumor areas 4 and 24&#xa0;h after injection, and SUV<sub>max</sub> and SUV<sub>mean</sub> were calculated. The ⊿tumor SUV (24&#xa0;h–4&#xa0;h) was calculated for each G1 and G2 by subtracting the SUV 4&#xa0;h from SUV 24&#xa0;h.</p> Results <p>The ⊿tumor SUV<sub>max</sub> (24&#xa0;h–4&#xa0;h) was 19.35 ± 23.26 in G1 and − 13.30 ± 20.26 in G2, and the ⊿tumor SUV<sub>mean</sub> (24&#xa0;h–4&#xa0;h) was 7.64 ± 15.58 in G1 and − 8.89 ± 15.45 in G2. The ⊿tumor SUV<sub>max</sub> (24&#xa0;h–4&#xa0;h) and ⊿tumor SUV<sub>mean</sub> (24&#xa0;h–4&#xa0;h) were higher in G1 compared to G2 (<i>p</i> &lt; 0.05).</p> Conclusion <p>The ⊿tumor SUV (24&#xa0;h–4&#xa0;h) in patients with pancreatic/gastrointestinal NET on <sup>111</sup>In-pentetreotide SPECT images were higher in G1 compared to G2. The ⊿tumor SUV (24&#xa0;h–4&#xa0;h) for pancreatic and gastrointestinal NETs may predict the malignancy grade, as determined by histological and pathological diagnosis.</p>

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Quantification of 111In-Pentetreotide Single Photon Emission Computed Tomography Images in Gastrointestinal Neuroendocrine Tumors and Possibility of Grade Prediction

  • 期刊论文

  • 发表日期：

    2025年2月18日

查看全文
  • Makoto Ohba,
  • Takeo Tanada,
  • Yasushi Ishikawa,
  • Satomi Teraoka,
  • Kazukuni Kirii,
  • Shin Ohara,
  • Ayato Taketa,
  • Taiyo Tanae,
  • Yosuke Moriya,
  • Koji Suzuki,
  • Masafumi Kanoto

摘要

Purpose

Neuroendocrine tumors (NETs) can be classified into three grades based on the malignancy index identified via histological and pathological diagnosis, and 111In-pentetreotide single photon emission computed tomography (SPECT) is effective for diagnosis. Therefore, this study aimed to distinguish between NET grade 1 (G1) and NET grade 2 (G2) based on the change in standardized uptake value (SUV) 4 and 24 h after injection in pancreatic and gastrointestinal NETs.

Methods

Twenty-two patients underwent 111In-pentetreotide SPECT and were definitively diagnosed with pancreatic or gastrointestinal NETs. The volume of interest were set in the tumor areas 4 and 24 h after injection, and SUVmax and SUVmean were calculated. The ⊿tumor SUV (24 h–4 h) was calculated for each G1 and G2 by subtracting the SUV 4 h from SUV 24 h.

Results

The ⊿tumor SUVmax (24 h–4 h) was 19.35 ± 23.26 in G1 and − 13.30 ± 20.26 in G2, and the ⊿tumor SUVmean (24 h–4 h) was 7.64 ± 15.58 in G1 and − 8.89 ± 15.45 in G2. The ⊿tumor SUVmax (24 h–4 h) and ⊿tumor SUVmean (24 h–4 h) were higher in G1 compared to G2 (p < 0.05).

Conclusion

The ⊿tumor SUV (24 h–4 h) in patients with pancreatic/gastrointestinal NET on 111In-pentetreotide SPECT images were higher in G1 compared to G2. The ⊿tumor SUV (24 h–4 h) for pancreatic and gastrointestinal NETs may predict the malignancy grade, as determined by histological and pathological diagnosis.