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<p>This study reports the first case of solitary brain metastasis from myxoid pleomorphic liposarcoma (MPLS) evaluated using <sup>18</sup>F-FAPI-04 PET/CT. The imaging revealed a distinct “Halo Sign,” reflecting the infiltration characteristics of cancer-associated fibroblasts (CAFs) within this rare tumor type. These findings highlight the utility of <sup>18</sup>F-FAPI-04 PET/CT in characterizing tumor heterogeneity and underscore its potential to improve the diagnosis of rare brain metastases while informing future therapeutic strategies.</p>

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18F-FAPI-04 PET/CT Imaging of Rare Brain Metastasis from Myxoid Pleomorphic Liposarcoma

  • 期刊论文

  • 发表日期：

    2025年1月6日

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  • Yong Wang,
  • Kelin Wang,
  • Dongfang Meng,
  • Kai Teng,
  • Zhiguo Liu,
  • Man Hu

摘要

This study reports the first case of solitary brain metastasis from myxoid pleomorphic liposarcoma (MPLS) evaluated using 18F-FAPI-04 PET/CT. The imaging revealed a distinct “Halo Sign,” reflecting the infiltration characteristics of cancer-associated fibroblasts (CAFs) within this rare tumor type. These findings highlight the utility of 18F-FAPI-04 PET/CT in characterizing tumor heterogeneity and underscore its potential to improve the diagnosis of rare brain metastases while informing future therapeutic strategies.