<p>The search for the renewal of Morocco’s regional industrial productive system requires alternative quantitative bases. Also, we propose to adapt the smart specialization framework to the regions of Morocco on the basis of their relatedness density and their complexity. To do this, we used data relating to exports, in 2015, of nearly 3000 establishments per region of Morocco, following 223 industrial activities. Thus, the historic industrial region of Casablanca-Settat has exhausted all the possibilities of the “high road” (high expected gain at low cost) and can only claim it through a greenfield establishment of companies. As for Tanger-Tétouan-Al Hoceïma, it can consider both a strategy of specialization along the high road and that of a strategic bet (high expected gain at high cost). On the other hand, the other peripheral regions (Drâa-Tafilalet, Guelmim-Oued Noun, Laâyoune-Sakia El Hamra and Eddakhla-Oued Eddahab) and landlocked regions (Béni Mellal-Khénifra) cannot claim any intelligent specialization strategy without improving their revealed comparative advantages of certain activities of which they are exporters. Thus, we were able to establish a coherent analytical framework of regional specialization to support sectoral and territorial public policy decisions. This prospective framework makes it possible to think about a diversification of regions towards new, more complex specializations, which rely on related local capabilities. This framework has the advantage of informing public decision-makers about the potential risks and benefits for regions of different diversification strategies.</p>