<p>In an uncertain world, businesses are increasingly interested in implementing enterprise management information technology (IT). Because information systems represent a crucial strategic management tool, IT must be implemented to enhance its effectiveness. Many organizations invest in IT solutions ranging from individual programs to integrated management systems to drive innovation and improve performance. However, studies on IT acceptance and effectiveness have not been conducted thoroughly. This study explored a path model by integrating innovation diffusion theory (IDT), the technology-organization-environment (TOE) framework, and psychological factors, namely attitude and behavioral intention to use software to interpret software adoption in information systems. This study also examined software adoption and firm performance based on the resource-based view (RBV). A PLS analysis based on data from 203 Vietnamese enterprises confirms that technological elements, including ICT infrastructure, perceived compatibility, and relative advantages, are correlated more strongly with software adoption than organizational and environmental elements. Behavioral intention plays a significant role in software acceptance, and software adoption increases organizational performance. These findings demonstrate that technological solutions and user behavioral intentions increase an organization’s acceptance of technological innovation. These results support business administrators in making technological innovation and development strategy decisions.</p>