Scholarlink

<p>Hepatocellular carcinoma is the most prevalent form of liver cancer worldwide and has high mortality rates. miRNAs, particularly miR-184, have been implicated in cancer biology, where they regulate gene expression and influence tumorigenesis. This study explored the role of miR-184 in HCC, revealing its dual function as both an oncogene and a tumor suppressor, depending on the target genes. We highlight the regulatory effects of miR-184 on critical genes such as <i>INPPL1</i>, <i>FOXO3a</i>, <i>MTSS</i>, <i>OSGIN1</i>, and <i>SOX7</i> and its impact on key signaling pathways, including the Wnt/β-catenin and JAK2/STAT3/AKT pathways. Dysregulation of miR-184 expression in HCC tissues compared with normal liver tissue was linked to increased proliferation, reduced apoptosis, and autophagy inhibition. Furthermore, miR-184 shows promise as a diagnostic and prognostic biomarker in HCC because of its altered expression in cancerous tissues and blood. Its regulation through circRNAs and lncRNAs such as lncRNA UCA1, circ_0004913, circ-0001141, circ-102,166, LINC00205, and SNHG11 adds a layer of complexity, challenging us to delve deeper into the intricate mechanisms of miR-184, positioning it as a crucial target for potential therapeutic intervention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

miR-184 in hepatocellular carcinoma: a promising therapeutic target

  • 期刊论文

  • 发表日期：

    2025年7月16日

查看全文
  • Leila Hosseinzadeh,
  • Fereshteh Jalilian,
  • Mohammad Reza Kalhori,
  • Reza Alibakhshi,
  • Amir Ali Kalhori,
  • Mohsen Karami

摘要

Hepatocellular carcinoma is the most prevalent form of liver cancer worldwide and has high mortality rates. miRNAs, particularly miR-184, have been implicated in cancer biology, where they regulate gene expression and influence tumorigenesis. This study explored the role of miR-184 in HCC, revealing its dual function as both an oncogene and a tumor suppressor, depending on the target genes. We highlight the regulatory effects of miR-184 on critical genes such as INPPL1, FOXO3a, MTSS, OSGIN1, and SOX7 and its impact on key signaling pathways, including the Wnt/β-catenin and JAK2/STAT3/AKT pathways. Dysregulation of miR-184 expression in HCC tissues compared with normal liver tissue was linked to increased proliferation, reduced apoptosis, and autophagy inhibition. Furthermore, miR-184 shows promise as a diagnostic and prognostic biomarker in HCC because of its altered expression in cancerous tissues and blood. Its regulation through circRNAs and lncRNAs such as lncRNA UCA1, circ_0004913, circ-0001141, circ-102,166, LINC00205, and SNHG11 adds a layer of complexity, challenging us to delve deeper into the intricate mechanisms of miR-184, positioning it as a crucial target for potential therapeutic intervention.