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<p>The HELT-E<sub>2</sub>S<sub>2</sub> score has recently been proposed as a new risk stratification tool for ischemic stroke in Japanese patients with atrial fibrillation (AF). We aimed to evaluate the prognostic value of HELT-E<sub>2</sub>S<sub>2</sub> score for cardiovascular events among patients undergoing percutaneous coronary intervention (PCI). Between August 2012 and July 2013, patients undergoing PCI enrolled in the SHINANO 5-year registry, a prospective, observational multicenter registry, were analyzed for the current study. Primary endpoint was major adverse cardiovascular events (MACE), a composite of all-cause death, myocardial infarction, and ischemic stroke at 5&#xa0;years. Key secondary endpoint was bleeding events at 5&#xa0;years. A total of 1608 patients were divided into the low HELT-E<sub>2</sub>S<sub>2</sub> score group (&lt; 2, n = 915) and high HELT-E<sub>2</sub>S<sub>2</sub> score group (≥ 2, n = 693). Major criteria of the HELT-E<sub>2</sub>S<sub>2</sub> score were hypertension (74.7%), elderly age 75–84&#xa0;years (31.3%), and AF (11.1%). Kaplan–Meier analysis revealed that the high HELT-E<sub>2</sub>S<sub>2</sub> score group had a significantly higher incidence of MACE (33.4% vs. 14.8%, P &lt; 0.001) and bleeding events (12.7% vs. 5.3%, P &lt; 0.001) compared with the low HELT-E<sub>2</sub>S<sub>2</sub> score group. Multivariable analysis demonstrated that the HELT-E<sub>2</sub>S<sub>2</sub> score remained significantly associated with MACE (hazard ratio: 1.73, 95% confidence interval: 1.11–2.69; P = 0.015). The HELT-E<sub>2</sub>S<sub>2</sub> score appears a useful tool for predicting future cardiovascular events in CAD patients undergoing PCI.</p> Graphical abstract <p></p>

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Prognostic value of HELT-E2S2 score among patients undergoing percutaneous coronary intervention: sub-analysis of the SHINANO 5-year registry

  • 期刊论文

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  • 发表日期：

    2025年3月29日

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  • Daisuke Sunohara,
  • Tatsuya Saigusa,
  • Yasushi Ueki,
  • Masatoshi Minamisawa,
  • Tadashi Itagaki,
  • Yoshiteru Okina,
  • Kiu Tanaka,
  • Hidetomo Nomi,
  • Tamon Kato,
  • Soichiro Ebisawa,
  • Takashi Miura,
  • Koichiro Kuwahara

摘要

The HELT-E2S2 score has recently been proposed as a new risk stratification tool for ischemic stroke in Japanese patients with atrial fibrillation (AF). We aimed to evaluate the prognostic value of HELT-E2S2 score for cardiovascular events among patients undergoing percutaneous coronary intervention (PCI). Between August 2012 and July 2013, patients undergoing PCI enrolled in the SHINANO 5-year registry, a prospective, observational multicenter registry, were analyzed for the current study. Primary endpoint was major adverse cardiovascular events (MACE), a composite of all-cause death, myocardial infarction, and ischemic stroke at 5 years. Key secondary endpoint was bleeding events at 5 years. A total of 1608 patients were divided into the low HELT-E2S2 score group (< 2, n = 915) and high HELT-E2S2 score group (≥ 2, n = 693). Major criteria of the HELT-E2S2 score were hypertension (74.7%), elderly age 75–84 years (31.3%), and AF (11.1%). Kaplan–Meier analysis revealed that the high HELT-E2S2 score group had a significantly higher incidence of MACE (33.4% vs. 14.8%, P < 0.001) and bleeding events (12.7% vs. 5.3%, P < 0.001) compared with the low HELT-E2S2 score group. Multivariable analysis demonstrated that the HELT-E2S2 score remained significantly associated with MACE (hazard ratio: 1.73, 95% confidence interval: 1.11–2.69; P = 0.015). The HELT-E2S2 score appears a useful tool for predicting future cardiovascular events in CAD patients undergoing PCI.

Graphical abstract