Scholarlink

<p>Knee osteoarthritis and degenerative spine conditions are among the most prevalent musculoskeletal disorders. Beyond degenerative changes, both entities are associated with chronic pain, low-grade systemic inflammation, and autonomic dysfunction characterized by relative&#xa0;sympathetic dominance. Targeted modulation of anti-inflammatory and analgesic parasympathetic pathways through vagus nerve stimulation therefore represents a&#xa0;promising therapeutic approach. Initial pilot studies investigating vagus nerve stimulation in knee osteoarthritis and degenerative spine conditions have demonstrated encouraging preliminary effects, particularly with respect to pain reduction. However, the current body of evidence remains heterogeneous. A&#xa0;key challenge for future research is thus to establish an optimal balance between standardized stimulation protocols and individualized application.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Autonome Neuromodulation in der Orthopädie: Vagusnerv-Stimulation als mögliche Therapieoption

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Robert Zahn,
  • Georg Pongratz,
  • Djaber Charef,
  • Moritz Oltmanns,
  • Patrik Ostermaier,
  • Constantin Schewe,
  • Felix Haußner,
  • Jörg Fiedler,
  • Zsuzsa Jenei-Lanzl

摘要

Knee osteoarthritis and degenerative spine conditions are among the most prevalent musculoskeletal disorders. Beyond degenerative changes, both entities are associated with chronic pain, low-grade systemic inflammation, and autonomic dysfunction characterized by relative sympathetic dominance. Targeted modulation of anti-inflammatory and analgesic parasympathetic pathways through vagus nerve stimulation therefore represents a promising therapeutic approach. Initial pilot studies investigating vagus nerve stimulation in knee osteoarthritis and degenerative spine conditions have demonstrated encouraging preliminary effects, particularly with respect to pain reduction. However, the current body of evidence remains heterogeneous. A key challenge for future research is thus to establish an optimal balance between standardized stimulation protocols and individualized application.