Detection and Separation of Paracetamol and p-Aminophenol Using Activated Glassy Carbon Electrodes
摘要
The square wave voltammetry (SWV) method was utilized to simultaneously find paracetamol and p-aminophenol (PAP) by applying an activated glassy carbon electrode (AGCE). The results showed that the AGCE effectively facilitated the oxidation of both compounds, exhibiting a significant separation of their oxidation peaks by approximately 280.5 mV, which is sufficient for their concurrent detection. The linear ranges and detection limits were found to be 6.0 × 10−7–1.0 × 10−4 mol L−1 and 1.0 × 10−6–8.0 × 10−4 mol L−1; 1.39 × 10−8 mol L−1 and 1.91 × 10−8 mol L−1 for APAP and PAP, correspondingly. Ultimately, the adopted method was effectively implemented to measure APAP and PAP in commercial-grade tablets, yielding average recoveries of 103.1% for APAP and 101.0% for PAP.
Graphical Abstract