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Background <p>Ubiquitination is a fundamental post-translational regulatory mechanism that controls protein stability, receptor signaling, immune modulation, and tumor cell fate. In lung cancer, it functions as a central regulatory axis integrating oncogenic signaling, tumor microenvironment remodeling, immune escape, and therapeutic response.</p> Methods <p>A bibliometric analysis was conducted on publications related to ubiquitination in lung cancer published between 2000 and August 2025. Data were retrieved from the Web of Science Core Collection and Scopus databases. Only English-language original articles and reviews were included, resulting in 2,093 records. CiteSpace, VOSviewer, and the Bibliometrix R package were used to evaluate publication trends, collaboration networks, influential authors, journals, citation patterns, and thematic evolution.</p> Results <p>Publication output showed a steady increase over the study period and accelerated markedly after 2015, reflecting the growing scientific attention in this field. China contributed the largest number of publications, while the United States showed the highest citation impact. Leading institutions such as Central South University and Fudan University formed extensive collaborative networks. Core journals included Frontiers in Oncology, Oncogene, and Journal of Biological Chemistry. Frontiers in Oncology represented a high-output open-access journal with broad disciplinary coverage. Keyword and citation analyses revealed that early research mainly focused on ubiquitin-mediated signaling and receptor-driven oncogenic mechanisms in lung cancer, while more recent studies expanded toward immune regulation, tumor microenvironment, and cancer stem cell related processes.The overall evolution demonstrates a shift from mechanistic molecular studies toward integrated biological and clinically relevant research frameworks.</p> Conclusions <p>This study provides a comprehensive international bibliometric overview based on English-language literature of ubiquitination research in lung cancer and highlights its progression from mechanistic foundations toward integrated regulatory networks involving oncogenic signaling, immune modulation, and therapeutic targeting, offering insights for future precision oncology research.</p>

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Global landscape and emerging trends of ubiquitination research in lung cancer based on a bibliometric analysis from 2000 to 2025

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Yan Li,
  • Shudan Deng,
  • Limantian Wang,
  • Lu Zhai,
  • Bomeng Zhao,
  • Huiyan Niu,
  • Lu Zhang,
  • Xiaoling Gao

摘要

Background

Ubiquitination is a fundamental post-translational regulatory mechanism that controls protein stability, receptor signaling, immune modulation, and tumor cell fate. In lung cancer, it functions as a central regulatory axis integrating oncogenic signaling, tumor microenvironment remodeling, immune escape, and therapeutic response.

Methods

A bibliometric analysis was conducted on publications related to ubiquitination in lung cancer published between 2000 and August 2025. Data were retrieved from the Web of Science Core Collection and Scopus databases. Only English-language original articles and reviews were included, resulting in 2,093 records. CiteSpace, VOSviewer, and the Bibliometrix R package were used to evaluate publication trends, collaboration networks, influential authors, journals, citation patterns, and thematic evolution.

Results

Publication output showed a steady increase over the study period and accelerated markedly after 2015, reflecting the growing scientific attention in this field. China contributed the largest number of publications, while the United States showed the highest citation impact. Leading institutions such as Central South University and Fudan University formed extensive collaborative networks. Core journals included Frontiers in Oncology, Oncogene, and Journal of Biological Chemistry. Frontiers in Oncology represented a high-output open-access journal with broad disciplinary coverage. Keyword and citation analyses revealed that early research mainly focused on ubiquitin-mediated signaling and receptor-driven oncogenic mechanisms in lung cancer, while more recent studies expanded toward immune regulation, tumor microenvironment, and cancer stem cell related processes.The overall evolution demonstrates a shift from mechanistic molecular studies toward integrated biological and clinically relevant research frameworks.

Conclusions

This study provides a comprehensive international bibliometric overview based on English-language literature of ubiquitination research in lung cancer and highlights its progression from mechanistic foundations toward integrated regulatory networks involving oncogenic signaling, immune modulation, and therapeutic targeting, offering insights for future precision oncology research.