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Introduction <p>To detect the expression of lncRNA endogenous bornavirus-like nucleoprotein (EBLN3P) in triple-negative breast cancer (TNBC) primary cells and tumor tissues. To explore the functional role of EBLN3P in the malignant progression of TNBC.</p> Methods <p>EBLN3P expression was detected by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Northern-blot (NB), the influence of EBLN3P to patients´ prognosis was explored by using Kaplan-Meier (K-M) survival analysis. siRNA was used to knockout EBLN3P in TNBC primary cells, 5-ethynyl-2´-deoxyuridine (EdU) and Transwells were used to evaluate changes in proliferation, migration and invasion abilities. RNA-sequence was used to explore changes of signaling pathway.</p> Results <p>EBLN3P was aberrantly upregulated in TNBC, especially those patients with distant metastasis. EBLN3P showed a tumor-promoting role, promoted the proliferation, migration and invasion abilities of TNBC by activating Wnt/β-catenin pathway.</p> Conclusion <p>EBLN3P might be a potential biomarker TNBC, especially for TNBC with distant metastasis.</p>

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lncRNA-EBLN3P promotes triple-negative breast cancer metastasis via activating Wnt/β-catenin signaling pathway

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月25日

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  • Ya-Hong Cai,
  • Jing-Jing Li,
  • Guang-Zhen Bai,
  • Can-Ming Fang,
  • Ye Zhao,
  • Jia-Rui Liu,
  • Yi-Jie Mei,
  • Hui-Hui Chen,
  • Rui Xue

摘要

Introduction

To detect the expression of lncRNA endogenous bornavirus-like nucleoprotein (EBLN3P) in triple-negative breast cancer (TNBC) primary cells and tumor tissues. To explore the functional role of EBLN3P in the malignant progression of TNBC.

Methods

EBLN3P expression was detected by using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Northern-blot (NB), the influence of EBLN3P to patients´ prognosis was explored by using Kaplan-Meier (K-M) survival analysis. siRNA was used to knockout EBLN3P in TNBC primary cells, 5-ethynyl-2´-deoxyuridine (EdU) and Transwells were used to evaluate changes in proliferation, migration and invasion abilities. RNA-sequence was used to explore changes of signaling pathway.

Results

EBLN3P was aberrantly upregulated in TNBC, especially those patients with distant metastasis. EBLN3P showed a tumor-promoting role, promoted the proliferation, migration and invasion abilities of TNBC by activating Wnt/β-catenin pathway.

Conclusion

EBLN3P might be a potential biomarker TNBC, especially for TNBC with distant metastasis.