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<p>Dipyridamole is a well-known antithrombotic and a vasodilator. It is used to treat cerebrovascular and cardiovascular diseases owing to its antiplatelet effects. Platelets play a key role in thrombosis and hemostasis, and after cancer cells enter the bloodstream, they interact with these cells to protect them and promote metastasis. Dipyridamole inhibits tumor progression by blocking platelet aggregation and platelet-mediated Epithelial-to-mesenchymal transition (EMT) via targeting the extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinases (MAPK) signaling pathway, further highlighting its potential antitumor properties. However, studies on the anti-tumor mechanisms of dipyridamole are currently limited and incomplete. In this review, we summarize the pathways through which dipyridamole disrupts platelet-tumor cell interactions and exerts antitumor effects, aiming to inform the development of novel anticancer therapies.</p>

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Antitumor effect of dipyridamole mediated by inhibiting the interaction between platelets and tumor cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月19日

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  • Jie Xue,
  • Jianzhao Deng,
  • Hongwei Qin,
  • Ying Li,
  • Zhongcui Jing,
  • Zhen Zhao,
  • Haiyan Wang

摘要

Dipyridamole is a well-known antithrombotic and a vasodilator. It is used to treat cerebrovascular and cardiovascular diseases owing to its antiplatelet effects. Platelets play a key role in thrombosis and hemostasis, and after cancer cells enter the bloodstream, they interact with these cells to protect them and promote metastasis. Dipyridamole inhibits tumor progression by blocking platelet aggregation and platelet-mediated Epithelial-to-mesenchymal transition (EMT) via targeting the extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinases (MAPK) signaling pathway, further highlighting its potential antitumor properties. However, studies on the anti-tumor mechanisms of dipyridamole are currently limited and incomplete. In this review, we summarize the pathways through which dipyridamole disrupts platelet-tumor cell interactions and exerts antitumor effects, aiming to inform the development of novel anticancer therapies.