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Background <p>Immune-related adverse events (irAEs) significantly impact the therapeutic efficacy of immune checkpoint inhibitors (ICIs) in lung cancer. However, a comprehensive understanding of the global research landscape and its evolution regarding irAEs is still lacking.</p> Methods <p>We conducted a bibliometric analysis of 6787 publications from the Web of Science Core Collection (2015–2024) via CiteSpace and the R-bibliometrix package. The analyses included cocitation, coauthorship, and keyword burst detection to map collaborative networks, knowledge structure, and research trends.</p> Results <p>Research output demonstrated a remarkable compound annual growth rate of 30.4%. INSERM (France) and US institutions appeared as central hubs in collaborative networks, whereas China—despite its high publication volume—showed more limited international integration, suggesting a productivity‑influence mismatch. The knowledge base comprises three clusters: clinical evidence, translational research, and fundamental immunology. Research themes evolved from initial tumor-agnostic safety reports to a focus on organ-specific irAEs and precision toxicology.</p> Conclusion <p>This study delineates the rapidly evolving landscape of irAE research in lung cancer immunotherapy, highlighting key collaborative patterns, knowledge structures, and thematic shifts. The findings provide a foundational perspective for guiding future research directions.</p>

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A comprehensive analysis and visualization of immune-related adverse events in lung cancer immunotherapy a bibliometric study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Xiongjie Li,
  • Fengyue Zhang,
  • Xuan Xu

摘要

Background

Immune-related adverse events (irAEs) significantly impact the therapeutic efficacy of immune checkpoint inhibitors (ICIs) in lung cancer. However, a comprehensive understanding of the global research landscape and its evolution regarding irAEs is still lacking.

Methods

We conducted a bibliometric analysis of 6787 publications from the Web of Science Core Collection (2015–2024) via CiteSpace and the R-bibliometrix package. The analyses included cocitation, coauthorship, and keyword burst detection to map collaborative networks, knowledge structure, and research trends.

Results

Research output demonstrated a remarkable compound annual growth rate of 30.4%. INSERM (France) and US institutions appeared as central hubs in collaborative networks, whereas China—despite its high publication volume—showed more limited international integration, suggesting a productivity‑influence mismatch. The knowledge base comprises three clusters: clinical evidence, translational research, and fundamental immunology. Research themes evolved from initial tumor-agnostic safety reports to a focus on organ-specific irAEs and precision toxicology.

Conclusion

This study delineates the rapidly evolving landscape of irAE research in lung cancer immunotherapy, highlighting key collaborative patterns, knowledge structures, and thematic shifts. The findings provide a foundational perspective for guiding future research directions.