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Background <p>Nuclear export mediator factor (NEMF) is considered to be a tumor suppressor in Drosophila. Based on the analysis of data from an online database, NEMF is downregulated in OV. However, the mechanism underlying its expression has not been reported thus far.</p> Results <p>In this study, the immunohistochemistry results showed that the expression of NEMF may be related to patient age and tissue differentiation. In vitro experiments indicated that overexpression of NEMF may inhibit cell proliferation and migration by inhibiting the PI3K/mTOR signaling pathway, thereby blocking cell cycle progression and promoting apoptosis (<i>P</i> &lt; 0.05). In vivo xenografts showed NEMF overexpression reduced tumor volume and proliferation markers (Ki-67, PCNA).</p> Conclusions <p>We speculate that NEMF is a potential tumor suppressor gene. Targeting NEMF may be an innovative therapeutic approach for OV.</p>

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NEMF inhibits the proliferation and migration of ovarian cancer cells by blocking the PI3K/mTOR pathway

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月14日

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  • Qian Wang,
  • Ying Zhu,
  • Chuangzhen Chen,
  • Jing Fan,
  • Ruifang Zeng,
  • Zike Yang,
  • Shanshan Song

摘要

Background

Nuclear export mediator factor (NEMF) is considered to be a tumor suppressor in Drosophila. Based on the analysis of data from an online database, NEMF is downregulated in OV. However, the mechanism underlying its expression has not been reported thus far.

Results

In this study, the immunohistochemistry results showed that the expression of NEMF may be related to patient age and tissue differentiation. In vitro experiments indicated that overexpression of NEMF may inhibit cell proliferation and migration by inhibiting the PI3K/mTOR signaling pathway, thereby blocking cell cycle progression and promoting apoptosis (P < 0.05). In vivo xenografts showed NEMF overexpression reduced tumor volume and proliferation markers (Ki-67, PCNA).

Conclusions

We speculate that NEMF is a potential tumor suppressor gene. Targeting NEMF may be an innovative therapeutic approach for OV.